Padmanabhan, S. , Du Toit, C. and Dominiczak, A. F. (2023) Cardiovascular precision medicine – a pharmacogenomic perspective. Cambridge Prisms: Precision Medicine, 1, pp. 1-54. e28. (doi: 10.1017/pcm.2023.17)
![[img]](https://eprints.gla.ac.uk/style/images/fileicons/text.png) |
Text
302587.pdf - Published Version Available under License Creative Commons Attribution. 683kB |
Abstract
Precision medicine envisages the integration of an individual’s clinical and biological features obtained from laboratory tests, imaging, high-throughput omics and health records, to drive a personalised approach to diagnosis and treatment with a higher chance of success. As only up to half of patients respond to medication prescribed following the current one-size-fits-all treatment strategy, the need for a more personalised approach is evident. One of the routes to transforming healthcare through precision medicine is pharmacogenomics (PGx). Around 95% of the population is estimated to carry one or more actionable pharmacogenetic variants and over 75% of adults over 50 years old are on a prescription with a known PGx association. Whilst there are compelling examples of pharmacogenomic implementation in clinical practice, the case for cardiovascular PGx is still evolving. In this review, we shall summarise the current status of PGx in cardiovascular diseases and look at the key enablers and barriers to PGx implementation in clinical practice.
| Item Type: | Articles |
|---|---|
| Additional Information: | S.P. and A.F.D. are supported by the British Heart Foundation Centre of Excellence Award (RE/18/6/34217) and the UKRI Strength in Places Fund (SIPF00007/1). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Padmanabhan, Professor Sandosh and Dominiczak, Professor Anna and Du Toit, Ms Clea |
| Authors: | Padmanabhan, S., Du Toit, C., and Dominiczak, A. F. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences |
| Journal Name: | Cambridge Prisms: Precision Medicine |
| Publisher: | Cambridge University Press |
| ISSN: | 2752-6143 |
| ISSN (Online): | 2752-6143 |
| Published Online: | 29 June 2023 |
| Copyright Holders: | Copyright © The Author(s), 2023 |
| First Published: | First published in Cambridge Prisms: Precision Medicine 1:e28 |
| Publisher Policy: | Reproduced under a Creative Commons license |
University Staff: Request a correction | Enlighten Editors: Update this record
Funder and Project Information
Funder and Project Information