Probiotic: is diet part of the efficacy equation?

Rytter, H., Combet, E. and Chassaing, B. (2023) Probiotic: is diet part of the efficacy equation? Gut Microbes, 15(1), 2222438. (doi: 10.1080/19490976.2023.2222438) (PMID:37381176) (PMCID:PMC10312016)

Abstract

Discovered at the beginning of the 20th century by Nobel laureate Élie Metchnikoff, probiotics have more recently emerged as a potential noninvasive therapeutic approach for the treatment of various chronic diseases. However, recent population-based clinical studies suggest that probiotics are often ineffective and may even exhibit potential deleterious effects. Hence, a deeper molecular understanding of strain-specific beneficial effects, together with the identification of endogenous/exogenous factors modulating probiotic efficacy, is needed. The lack of consistency in probiotic efficacy, together with the observation that numerous preclinical findings on probiotics are not translating once applied to humans through clinical trials, suggests a central role for environmental factors, such as dietary patterns, in probiotic efficacy. Two recent studies have been instrumental in filling this knowledge gap, defining the role played by diet in probiotic efficacy on metabolic deregulations in both mouse models and humans .

• Item Type: Articles
• Additional Information: BC’s laboratory is supported by a Starting Grant from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement No. ERC-2018-StG- 804135), an award from the Fondation de l’avenir (AP-RM-21-032), ANR grants EMULBIONT (ANR-21-CE15-0042-01) and DREAM (ANR-20-PAMR-0002) and the national program “Microbiote” from INSERM.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Combet Aspray, Professor Emilie
• Authors: Rytter, H., Combet, E., and Chassaing, B.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Gut Microbes
• Publisher: Taylor and Francis
• ISSN: 1949-0976
• ISSN (Online): 1949-0984
• Published Online: 28 June 2023
• Copyright Holders: Copyright © 2023 The Authors
• First Published: First published in Gut Microbe 15(1): 2222438
• Publisher Policy: Reproduced under a Creative Commons License