Fragoulis, G. E., Vetsika, E.-K., Kyriakidi, M., Verrou, K.-M., Kollias, G., Tektonidou, M. G., McInnes, I. B. and Sfikakis, P. P. (2023) Distinct innate and adaptive immunity phenotypic profile at the circulating single-cell level in psoriatic arthritis. Clinical Immunology, 253, 109679. (doi: 10.1016/j.clim.2023.109679) (PMID:37336253)
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Abstract
Mass cytometry was employed to investigate 47 circulating leukocyte subsets in patients with active psoriatic arthritis (PsA, n = 16) compared to healthy controls (n = 13), seropositive (RF and/or anti-CCP, n = 12) and seronegative (n = 9) RA patients. Comparing PsA to controls, different cell frequencies were found in both innate and adaptive immunity cell subsets, as well as in cells bridging innate and adaptive immunity. In some T cell subsets increased costimulatory molecules' expression in PsA, was also noted.No changes were observed in patients who remained disease-active after 3 months of treatment, in contrast to those who achieved remission/low-disease activity. Comparing PsA to seropositive RA, elevated frequencies of naïve and activated CD8+ T cells, B cells, MAIT/iNKT and ILCs were found, while the opposite was the case for terminal effector, senescent, and Th2-like cells. Strikingly, the composition of the leukocyte pool in PsA was comparable to seronegative RA, providing evidence for the pathogenetic similarities between these two entities.
| Item Type: | Articles |
|---|---|
| Additional Information: | This study is funded by the Hellenic Rheumatology Society and the Professional Association of Rheumatologists (Protocol Number: 2021/1084) and the medical education grant of Novartis (ID70865649). |
| Keywords: | Mass cytometry, psoriatic arthritis, immunophenotyping, CyTOF, peripheral blood. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McInnes, Professor Iain and Fragkoulis, Dr Georgios |
| Authors: | Fragoulis, G. E., Vetsika, E.-K., Kyriakidi, M., Verrou, K.-M., Kollias, G., Tektonidou, M. G., McInnes, I. B., and Sfikakis, P. P. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Research Centre: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology |
| Journal Name: | Clinical Immunology |
| Publisher: | Elsevier |
| ISSN: | 1521-6616 |
| ISSN (Online): | 1521-7035 |
| Published Online: | 17 June 2023 |
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