Synthesis of methotrexate loaded dumbbell-shaped titanium dioxide/gold nanorods coated with mesoporous silica and decorated with upconversion nanoparticles for near-infrared driven trimodal cancer treatment

Dash, P., Thirumurugan, S., Tseng, C.-L., Lin, Y.-C., Chen, S.-L., Dhawan, U. and Chung, R.-J. (2023) Synthesis of methotrexate loaded dumbbell-shaped titanium dioxide/gold nanorods coated with mesoporous silica and decorated with upconversion nanoparticles for near-infrared driven trimodal cancer treatment. ACS Applied Materials and Interfaces, 15(28), pp. 33335-33347. (doi: 10.1021/acsami.3c04300) (PMID:37403930)

Abstract

This study prepared dumbbell-shaped titanium dioxide (TiO2)/gold nanorods (AuNRs) coated with mesoporous silica shells (mS) (AuNRs-TiO2@mS). Methotrexate (MTX) was further loaded into the AuNRs-TiO2@mS, and then upconversion nanoparticles (UCNPs) were decorated to form AuNRs-TiO2@mS-MTX: UCNP nanocomposites. TiO2 is used as an intense photosensitizer (PS) to produce cytotoxic reactive oxygen species (ROS), leading to photodynamic therapy (PDT). Concurrently, AuNRs exhibited intense photothermal therapy (PTT) effects and photothermal conversion efficiency. In vitro results suggested that these nanocomposites can kill oral cancer cells (HSC-3) without toxicity through irradiation of NIR laser, owing to the synergistic effect. The in vivo studies indicated that these nanocomposites exhibited excellent antitumor effects through synergistic PDT/PTT/chemotherapy under a near-infrared (NIR) 808 nm laser irradiation. Thus, these AuNRs-TiO2@mS: UCNP nanocomposites have great potential to undergo deep tissue penetration with enhanced synergistic effects through NIR-triggered light for cancer treatment.

• Item Type: Articles
• Additional Information: The authors are grateful for the financial support provided by the Ministry of Science and Technology of Taiwan (MOST111-2221-E-027-105).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Dhawan, Dr Udesh

Creator Roles

Dhawan, U.: Formal analysis, Software, Validation, Visualization

• Authors: Dash, P., Thirumurugan, S., Tseng, C.-L., Lin, Y.-C., Chen, S.-L., Dhawan, U., and Chung, R.-J.
• College/School: College of Science and Engineering > School of Engineering > Biomedical Engineering
• Journal Name: ACS Applied Materials and Interfaces
• Publisher: American Chemical Society
• ISSN: 1944-8244
• ISSN (Online): 1944-8252
• Published Online: 05 July 2023
• Copyright Holders: Copyright © 2023 American Chemical Society
• First Published: First published in ACS Applied Materials and Interfaces 15(28):33335-33347
• Publisher Policy: Reproduced in accordance with the publisher copyright policy