Docherty, K. F. , Jackson, A. M., Macartney, M., Campbell, R. T., Petrie, M. C. , Pfeffer, M. A., McMurray, J. J.V. and Jhund, P. S. (2023) Declining risk of heart failure hospitalization following first acute myocardial infarction in Scotland between 1991–2016. European Journal of Heart Failure, 25(8), pp. 1213-1224. (doi: 10.1002/ejhf.2965) (PMID:37401485)
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Abstract
Background: Mortality from acute myocardial infarction (AMI) has declined, increasing the pool of survivors at risk of later development of heart failure (HF). However, coronary reperfusion limits infarct size and secondary prevention therapies have improved. In light of these competing influences, we examined long-term trends in the risk of HF hospitalization (HFH) following a first AMI occurring in Scotland over 25 years. Methods: All patients in Scotland discharged alive after a first AMI between 1991 and 2015 were followed until a first HFH or death until the end of 2016 (minimum follow-up 1 year, maximum 26 years). Results: A total of 175 672 people with no prior history of HF were discharged alive after a first AMI during the period of study. 21 445 (12.2%) had a first HFH during a median follow-up of 6.7 years. Incidence of HFH (per 1000 person-years) at 1 year following discharge from a first AMI decreased from 59.3 (95%CI 54.2–64.7) in 1991 to 31.3 (27.3–35.8) in 2015, with consistent trends seen for HF occurring within 5 and 10 years. Accounting for the competing risk of death, the adjusted risk of HFH at 1 year after discharge decreased by 53% (95%CI 45%–60%), with similar decreases at 5 and 10 years. Conclusion: The incidence of HF hospitalization following AMI in Scotland has decreased since 1991. These trends suggest that better treatment of AMI and secondary prevention are having an impact on the risk of HF at a population level.
| Item Type: | Articles |
|---|---|
| Additional Information: | This work was funded by an National Health Service Greater Glasgow and Clyde Endowment fund award (GN17CA406). Mark C. Petrie, John J.V. McMurray, and Pardeep S. Jhund are supported by British Heart Foundation Centre of Research Excellence (Grant RE/18/6/34217) and the Vera Melrose Heart Failure Research Fund. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Docherty, Dr Kieran and Jackson, Dr Alice and Jhund, Professor Pardeep and Campbell, Dr Ross and McMurray, Professor John and Petrie, Professor Mark |
| Authors: | Docherty, K. F., Jackson, A. M., Macartney, M., Campbell, R. T., Petrie, M. C., Pfeffer, M. A., McMurray, J. J.V., and Jhund, P. S. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | European Journal of Heart Failure |
| Publisher: | Wiley |
| ISSN: | 1388-9842 |
| ISSN (Online): | 1879-0844 |
| Published Online: | 04 July 2023 |
| Copyright Holders: | Copyright © 2023 The Authors |
| First Published: | First published in European Journal of Heart Failure 25(8):1213-1224 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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