Plasma levels of coagulation factors VIII and IX and risk of venous thromboembolism: systematic review and meta-analysis

Lowe, G., Wu, O. , van Hylckama Vlieg, A., Folsom, A., Rosendaal, F. and Woodward, M. (2023) Plasma levels of coagulation factors VIII and IX and risk of venous thromboembolism: systematic review and meta-analysis. Thrombosis Research, 229, pp. 31-39. (doi: 10.1016/j.thromres.2023.06.026)

Abstract

Introduction: The associations of plasma factor VIII (FVIII) and factor IX (FIX) levels with risk of venous thromboembolism (VTE) are not well defined. We performed a systematic review and meta-analysis of these associations. Methods: Random effects inverse-variance weighted meta-analysis was used to estimate pooled odds ratios for comparisons across equal quartiles of the distributions and 90 % thresholds (higher versus lower), and for testing linear trends. Results: Among 15 studies (5327 cases) the pooled odds ratio of VTE for the fourth versus first quarter was 3.92 (95 % confidence interval 1.61, 5.29) for FVIII level; and among 7 studies (3498 cases) 1.57 (1.32, 1.87) for FIX level. Comparing factor levels above, versus below, the 90th percentile, the estimated pooled odds ratios were 3.00 (2.10, 4.30) for FVIII; 1.77 (1.22, 2.56) for FIX; and 4.56 (2.73, 7.63) for both FVIII and FIX considered jointly. Conclusions: We confirm increases in risk of VTE across population distributions of FVIII and FIX levels. Levels above the 90th percentile have almost twice the risk for FIX level compared to levels below; three-fold risk for FVIII level; and almost five-fold risk for both FVIII and FIX levels elevated.

• Item Type: Articles
• Additional Information: Freeline Therapeutics, London provided institutional funding to support the literature search, data extraction and statistical analysis; but had no role in the design, conduct, or drafting of this report.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Woodward, Professor Mark and Wu, Professor Olivia and Lowe, Professor Gordon
• Authors: Lowe, G., Wu, O., van Hylckama Vlieg, A., Folsom, A., Rosendaal, F., and Woodward, M.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Health Economics and Health Technology Assessment
• Journal Name: Thrombosis Research
• Publisher: Elsevier
• ISSN: 0049-3848
• ISSN (Online): 1879-2472
• Published Online: 28 June 2023
• Copyright Holders: Copyright © 2023 The Authors
• First Published: First published in Thrombosis Research 229: 31-39
• Publisher Policy: Reproduced under a Creative Commons License