Vitamin K and hallmarks of ageing: focus on diet and gut microbiome

Dai, L., Mafra, D. , Shiels, P. G. , Hackeng, T. M., Stenvinkel, P. and Schurgers, L. J. (2023) Vitamin K and hallmarks of ageing: focus on diet and gut microbiome. Nutrients, 15(12), 2727. (doi: 10.3390/nu15122727) (PMID:37375631) (PMCID:PMC10301624)

Abstract

Vitamin K and vitamin K-dependent proteins have been reported to be associated with a large spectrum of age-related diseases. While most of these associations have been deduced from observational studies, solid evidence for the direct impact of vitamin K on cellular senescence remains to be proven. As vitamin K status reflects the complexity of interactions between dietary intake, gut microbiome activity and health, we will demonstrate the pivotal role of the diet-microbiome-health axis in human ageing and exemplify how vitamin K is implicated therein. We propose that food quality (i.e., food pattern) should be highlighted beyond the quantity of total vitamin K intake. Instead of focusing on a single nutrient, exploring a healthy diet containing vitamin K may be more strategic. As such, healthy eating patterns can be used to make dietary recommendations for the public. Emerging evidence suggests that dietary vitamin K is a modulator of the diet-microbiome-health axis, and this needs to be incorporated into the investigation of the impact of vitamin K on gut microbial composition and metabolic activities, along with host health outcomes. In addition, we highlight several critical caveats that need to be acknowledged regarding the interplay between diet, vitamin K, gut microbiome and host health that is pivotal for elucidating the role of vitamin K in ageing and responding to the urgent call of healthy eating concerning public health.

• Item Type: Articles
• Additional Information: This research was funded by Strategic Research Program in Diabetes at Karolinska Institutet (Swedish Research Council grant No 2009-1068), European Union’s Horizon 2020 research and innovation Program under the Marie Skłodowska-Curie grant agreement No 722609; Heart and Lung Foundation (PS), CIMED (PS), Njurfonden (PS), and Westmans Foundation (PS).
• Keywords: Vitamin K, Ageing, Gut microbiome, food pattern.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Mafra, Prof Denise and Shiels, Professor Paul

Creator Roles

Mafra, D.: Investigation, Writing – review and editing, Visualization
Shiels, P. G.: Investigation, Writing – review and editing

• Authors: Dai, L., Mafra, D., Shiels, P. G., Hackeng, T. M., Stenvinkel, P., and Schurgers, L. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Nutrients
• Publisher: MDPI
• ISSN: 2072-6643
• ISSN (Online): 2072-6643
• Published Online: 12 June 2023
• Copyright Holders: Copyright © 2023 The Authors
• First Published: First published in Nutrients 15(12): 2727
• Publisher Policy: Reproduced under a Creative Commons License