Bennet, C. L. and Perona-Wright, G. (2023) Metabolic adaption of mucosal macrophages: is metabolism a driver of persistence across tissues? Mucosal Immunology, 16(5), pp. 753-763. (doi: 10.1016/j.mucimm.2023.06.006) (PMID:37385586) (PMCID:PMC10564628)
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Abstract
Macrophages play essential roles in tissue homeostasis, defense, and repair. Their functions are highly tissue-specific, and when damage and inflammation stimulate repopulation by circulating monocytes, the incoming monocytes rapidly acquire the same, tissue-specific functions as the previous, resident macrophages. Several environmental factors are thought to guide the functional differentiation of recruited monocytes, including metabolic pressures imposed by the fuel sources available in each tissue. Here we discuss whether such a model of metabolic determinism can be applied to macrophage differentiation across barrier sites, from the lung to the skin. We suggest an alternative model, in which metabolic phenotype is a consequence of macrophage longevity rather than an early driver of tissue-specific adaption.
Item Type: | Articles |
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Additional Information: | C.B. is funded by Biotechnology and Biological Sciences Research Council, grant BB/T005246/1, and G.P-W by the Medical Research Council, grant MR/S009779/1. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Perona-Wright, Dr Georgia |
Authors: | Bennet, C. L., and Perona-Wright, G. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Mucosal Immunology |
Publisher: | Elsevier |
ISSN: | 1933-0219 |
ISSN (Online): | 1935-3456 |
Published Online: | 15 July 2023 |
Copyright Holders: | Copyright © 2023 The Authors |
First Published: | First published in Mucosal Immunology 16(5): 753-763 |
Publisher Policy: | Reproduced under a Creative Commons License |
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