Mechanisms of acute right ventricular injury in cardiothoracic surgical and critical care settings, Part 1

Zochios, V. et al. (2023) Mechanisms of acute right ventricular injury in cardiothoracic surgical and critical care settings, Part 1. Journal of Cardiothoracic and Vascular Anesthesia, (doi: 10.1053/j.jvca.2023.06.014) (Early Online Publication)

Abstract

Right ventricular biomechanics play a key role in maintaining cardiovascular homeostasis in cardiothoracic surgical settings. The interplay between the right ventricle and pulmonary vasculature, the so called ventriculo-arterial coupling determines the response of the right ventricle to different loading conditions and its interaction with the left ventricle in order to meet flow demand. There is a lack of universal right ventricular injury definition since it represents a range of abnormal right ventricular biomechanics and phenotypes: from diastolic dysfunction to right ventricular failure and shock. Understanding the mechanisms of uncoupling between the right ventricle and pulmonary circulation as well as primary right ventricular insult may inform future research, particularly phenotyping of right ventricular injury which may aid in individualizing right ventricle-targeted therapies. In this narrative review, the authors discuss the mechanisms of right ventricular injury in cardiac and thoracic surgical settings and implications for practice.

• Item Type: Articles
• Status: Early Online Publication
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Shelley, Dr Benjamin
• Authors: Zochios, V., Shelley, B., Antonini, M. V., Chawla, S., Sato, R., Dugar, S., Valchanov, K., Roscoe, A., Scott, J., Bangash, M. N., Akhtar, W., Rosenberg, A., Dimarakis, I., Khorsandi, M., and Yusuff, H.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Journal of Cardiothoracic and Vascular Anesthesia
• Publisher: Elsevier
• ISSN: 1053-0770
• ISSN (Online): 1532-8422
• Published Online: 12 June 2023