A look-locker acquisition scheme for quantitative myocardial perfusion imaging with FAIR arterial spin labeling in humans at 3 tesla

Keith, G. A. , Rodgers, C. T., Chappell, M. A. and Robson, M. D. (2017) A look-locker acquisition scheme for quantitative myocardial perfusion imaging with FAIR arterial spin labeling in humans at 3 tesla. Magnetic Resonance in Medicine, 78(2), pp. 541-549. (doi: 10.1002/mrm.26388) (PMID:27604183) (PMCID:PMC5516148)

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Purpose: A novel method for quantitative measurement of myocardial blood flow (MBF) using arterial spin labeling (ASL) in a single breath-hold is presented, evaluated by simulations, phantom studies and in vivo studies and tested for reproducibility and variability. Methods: A flow-sensitive alternating inversion recovery (FAIR) ASL method with Look-Locker readout (LL-FAIR-ASL) was implemented at 3 tesla. Scans were performed on 10 healthy volunteers and MBF measured in three slices. The method was investigated for reproducibility by Bland-Altman analysis and statistical measures, the coefficients of reproducibility (CR) and variation (CV) are reported. Results: The MBF values for the basal, mid, and apical slices were 1.04 ± 0.40, 1.06 ± 0.46, and 1.06 ± 0.38 ml/g/min, respectively (mean ± SD), which compare well with literature values. The CV across all scans, 43%, was greater than the between-session and within-session values, at 16 and 13%, respectively, for the mid-ventricular slice. The change in MBF required for detection, from the CR, was 61% between-session and 53% within-session for the mid-ventricle. Conclusion: This study shows the feasibility of the LL-FAIR-ASL method for the quantification of MBF. The statistical measures reported will allow the planning of future clinical research studies involving rest and stress measurements.

Item Type:Articles
Additional Information:C.T.R. is funded by the Wellcome Trust and the Royal Society.
Glasgow Author(s) Enlighten ID:Keith, Dr Graeme
Authors: Keith, G. A., Rodgers, C. T., Chappell, M. A., and Robson, M. D.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Magnetic Resonance in Medicine
ISSN (Online):1522-2594
Published Online:08 September 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Magnetic Resonance in Medicine 78(2):541-549
Publisher Policy:Reproduced under a Creative Commons licence

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