Excretion by subjects on a low (poly)phenol diet of phenolic gut microbiota catabolites sequestered in tissues or associated with catecholamines and surplus amino acids

Pereira-Caro, G. et al. (2023) Excretion by subjects on a low (poly)phenol diet of phenolic gut microbiota catabolites sequestered in tissues or associated with catecholamines and surplus amino acids. International Journal of Food Sciences and Nutrition, 74(4), pp. 532-543. (doi: 10.1080/09637486.2023.2226369) (PMID:37369137)

Abstract

Phenolic catabolites excreted by fasting subjects with a functioning colon and ileostomists on a low (poly)phenol diet have been investigated. Urine was collected over a 12 h fasting period after adherence to a low (poly)phenol diet for 36 h. UHPLC-HR-MS quantified 77 phenolics. Some were present in the urine of both groups in similar trace amounts and others were excreted in higher amounts by participants with a colon indicating the involvement of the microbiota. Most were present in sub- or low-µmol amounts, but hippuric acid dominated accounting on average for 60% of the total for both volunteer categories indicating significant production from sources other than non-nutrient dietary (poly)phenols. The potential origins of the phenolics associated with the low (poly)phenol diet, include endogenous catecholamines, surplus tyrosine and phenylalanine, and washout of catabolites derived from pre-study intakes of non-nutrient dietary (poly)phenols.

• Item Type: Articles
• Additional Information: Funding: A.C., T.M.A. and G.P.-C. were funded by the Distinguished Scientist Fellowship Program (DSFP) of King Saud University, Riyadh, Saudi Arabia. G.P.-C. was also supported by the grant RTI2018-096703-J-I00 from the Spanish State Research Agency (AEI) and by the ‘Programa Emergia 2020’ from the Secretaría General de Universidades, Investigación e Innovación, Junta de Andalucía. S.C.-J. is supported by a predoctoral fellowship funded by the Spanish Ministry of Universities (FPU20/03549).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Crozier, Professor Alan
• Authors: Pereira-Caro, G., Cáceres-Jimenez, S., Bresciani, L., Mena, P., Altmutairi, T. M., Dobani, S., Pourshahidi, L. K., Gill, C. I.R., Moreno Rojas, J. M., Clifford, M. N., and Crozier, A.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: International Journal of Food Sciences and Nutrition
• Publisher: Taylor & Francis
• ISSN: 0963-7486
• ISSN (Online): 1465-3478
• Published Online: 27 June 2023
• Copyright Holders: Copyright © 2023 Taylor & Francis Group, LLC
• First Published: First published in International Journal of Food Sciences and Nutrition 74(4): 532-543
• Publisher Policy: Reproduced in accordance with the publisher copyright policy