Nathavitharana, R. R. et al. (2019) Guidance for studies evaluating the accuracy of tuberculosis triage tests. Journal of Infectious Diseases, 220(3), S116-S125. (doi: 10.1093/infdis/jiz243) (PMID:31593600) (PMCID:PMC6782021)
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Abstract
Approximately 3.6 million cases of active tuberculosis (TB) go potentially undiagnosed annually, partly due to limited access to confirmatory diagnostic tests, such as molecular assays or mycobacterial culture, in community and primary healthcare settings. This article provides guidance for TB triage test evaluations. A TB triage test is designed for use in people with TB symptoms and/or significant risk factors for TB. Triage tests are simple and low-cost tests aiming to improve ease of access and implementation (compared with confirmatory tests) and decrease the proportion of patients requiring more expensive confirmatory testing. Evaluation of triage tests should occur in settings of intended use, such as community and primary healthcare centers. Important considerations for triage test evaluation include study design, population, sample type, test throughput, use of thresholds, reference standard (ideally culture), and specimen flow. The impact of a triage test will depend heavily on issues beyond accuracy, primarily centered on implementation.
| Item Type: | Articles |
|---|---|
| Additional Information: | R. R. N. is funded by a National Institutes of Health Career Development Award (National Institute of Allergy and Infectious Diseases [NIAID] K23 AI13264801A1) and American Society of Tropical Medicine and Hygiene Burroughs Wellcome Fellowship. She acknowledges prior funding from a Harvard Center for AIDS Research Scholar Award (NIAID 2P30AI060354-11). C. Y. is funded by a National Institutes of Health Career Development Award (NIAID K23 AI114363). P. M. is funded by the Wellcome Trust (206575). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | MacPherson, Professor Peter |
| Authors: | Nathavitharana, R. R., Yoon, C., MacPherson, P., Dowdy, D. W., Cattamanchi, A., Somoskovi, A., Broger, T., Ottenhoff, T. H.M., Arinaminpathy, N., Lonnroth, K., Reither, K., Cobelens, F., Gilpin, C., Denkinger, C. M., and Schumacher, S. G. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health |
| Journal Name: | Journal of Infectious Diseases |
| Publisher: | Oxford University Press |
| ISSN: | 0022-1899 |
| ISSN (Online): | 1537-6613 |
| Published Online: | 08 October 2019 |
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