Wang, H., Manzano, J. S., Kitson, P. J., Mullin, M., Lin, C.-G., Slowing, I. I. and Cronin, L. (2023) Digitizing protocols into single reactors for the one-pot synthesis of nanomaterials. Matter, 6(7), pp. 2383-2394. (doi: 10.1016/j.matt.2023.05.029)
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Abstract
Nanomaterials exhibit unique properties that are tunable depending on their morphology and composition. However, widely used methods can fail due to incomplete or assumed knowledge of the synthesis protocol. A digital synthesis method could unambiguously capture the synthesis process, including required hardware, reagent inputs, and process description, thereby increasing accessibility and improving reproducibility. Our method encodes synthetic procedures into single reactors by imprinting synthetic parameters to the reactor’s morphology, which are described using a chemical description language, χDL. This approach is consolidated into three single reactors that automate complex processes such as one-time, dropwise, and sequential addition for the synthesis of eight time-resolved CdSe quantum dots, CdSe@ZnSe core-shell nanoparticles, and Pt-Fe3O4 Janus nanoparticles, respectively. This method of translating synthetic parameters into physical instances of a reactor enables the automation of nanomaterial synthesis in a simple, reliable, and reproducible manner, making nanomaterials accessible to researchers from various fields on demand.
| Item Type: | Articles |
|---|---|
| Additional Information: | We gratefully acknowledge financial support from the EPSRC (grant nos. EP/L023652/1, EP/R020914/1, EP/S030603/1, EP/R01308X/1, EP/S017046/1, and EP/S019472/1), the ERC (project no. 670467 SMART-POM), the EC (project no. 766975 MADONNA), and DARPA (project nos. W911NF-18- 2-0036, W911NF-17-1-0316, and HR001119S0003). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Lin, Dr Chang-Gen and Manzano, Dr Sebastian and Wang, Hsin and Cronin, Professor Lee and Mullin, Mrs Margaret and Kitson, Dr Philip |
| Authors: | Wang, H., Manzano, J. S., Kitson, P. J., Mullin, M., Lin, C.-G., Slowing, I. I., and Cronin, L. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Science and Engineering College of Science and Engineering > School of Chemistry |
| Journal Name: | Matter |
| Publisher: | Elsevier (Cell Press) |
| ISSN: | 2590-2385 |
| ISSN (Online): | 2590-2385 |
| Published Online: | 12 June 2023 |
| Copyright Holders: | Copyright © 2023 The Authors |
| First Published: | First published in Matter 6(7):2383-2394 |
| Publisher Policy: | Reproduced under a Creative Commons license |
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