Lyall, D. M. et al. (2023) Artificial intelligence for dementia—applied models and digital health. Alzheimer's and Dementia, (doi: 10.1002/alz.13391) (PMID:37496259) (Early Online Publication)
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Abstract
Introduction: The use of applied modeling in dementia risk prediction, diagnosis, and prognostics will have substantial public health benefits, particularly as “deep phenotyping” cohorts with multi-omics health data become available. Methods: This narrative review synthesizes understanding of applied models and digital health technologies, in terms of dementia risk prediction, diagnostic discrimination, prognosis, and progression. Machine learning approaches show evidence of improved predictive power compared to standard clinical risk scores in predicting dementia, and the potential to decompose large numbers of variables into relatively few critical predictors. Results: This review focuses on key areas of emerging promise including: emphasis on easier, more transparent data sharing and cohort access; integration of high-throughput biomarker and electronic health record data into modeling; and progressing beyond the primary prediction of dementia to secondary outcomes, for example, treatment response and physical health. Discussion: Such approaches will benefit also from improvements in remote data measurement, whether cognitive (e.g., online), or naturalistic (e.g., watch-based accelerometry).
| Item Type: | Articles |
|---|---|
| Status: | Early Online Publication |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Petermann-Rocha, Mrs Fanny and Lyall, Dr Donald and Buckley, Professor Christopher and Sousa, Dr Jose |
| Authors: | Lyall, D. M., Kormilitzin, A., Lancaster, C., Sousa, J., Petermann-Rocha, F., Buckley, C., Harshfield, E. L., Iveson, M. H., Madan, C. R., McArdle, R., Newby, D., Orgeta, V., Tang, E., Tamburin, S., Thakur, L. S., Lourida, I., The Deep Dementia Phenotyping (DEMON) Network, , Llewellyn, D. J., and Ranson, J. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Alzheimer's and Dementia |
| Publisher: | Wiley |
| ISSN: | 1552-5260 |
| ISSN (Online): | 1552-5279 |
| Published Online: | 26 July 2023 |
| Copyright Holders: | Copyright © 2023 The Authors |
| First Published: | First published in Alzheimer's and Dementia 2023 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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