Acute fatty liver disease after suprasellar tumor resection

Evans, H. M., Shaikh, M. G., McKiernan, P. J., Hockley, A. D., Crowne, E. C., Kirk, J. M.W. and Kelly, D. A. (2004) Acute fatty liver disease after suprasellar tumor resection. Journal of Pediatric Gastroenterology and Nutrition, 39(3), pp. 288-291. (doi: 10.1097/00005176-200409000-00012) (PMID:15319631)

Abstract

Suprasellar tumors of the hypothalamus and pituitary gland, such as craniopharyngiomas, account for approximately 7% of intracranial tumors in childhood (1,2). The usual treatment is neurosurgical excision, and sequelae include pituitary dysfunction and hyperphagia with weight gain. Complications may occur before surgery as a result of the position of the tumor or after neurosurgical excision (2). Fatty liver disease is is now increasingly recognized in developed countries in relation to obesity, insulin resistance and type 2 diabetes mellitus (3). We present four cases of fatty liver that occurred acutely after excision of suprasellar tumors. In all cases, long-term evidence of fatty liver has been observed. One child developed cirrhosis with portal hypertension. This phenomenon has not previously been reported, and it highlights the need to monitor liver function in patients with suprasellar tumors.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Shaikh, Dr Mohammed Guftar
• Authors: Evans, H. M., Shaikh, M. G., McKiernan, P. J., Hockley, A. D., Crowne, E. C., Kirk, J. M.W., and Kelly, D. A.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Journal of Pediatric Gastroenterology and Nutrition
• Publisher: Lippincott, Williams & Wilkins
• ISSN: 0277-2116
• ISSN (Online): 1536-4801