Insights into the pathophysiology of catch-up compared with non-catch-up growth in children born small for gestational age: An integrated analysis of metabolic and transcriptomic data

Stevens, A. et al. (2014) Insights into the pathophysiology of catch-up compared with non-catch-up growth in children born small for gestational age: An integrated analysis of metabolic and transcriptomic data. Pharmacogenomics Journal, 14, pp. 376-384. (doi: 10.1038/tpj.2014.4) (PMID:24614687)

Abstract

Small for gestational age (SGA) children exhibiting catch-up (CU) growth have a greater risk of cardiometabolic diseases in later life compared with non-catch-up (NCU) SGA children. The aim of this study was to establish differences in metabolism and gene expression profiles between CU and NCU at age 4–9 years. CU children (n=22) had greater height, weight and body mass index standard deviation scores along with insulin-like growth factor-I (IGF-I) and fasting glucose levels but lower adiponectin values than NCU children (n=11; all P<0.05). Metabolic profiling demonstrated a fourfold decrease of urine myo-inositol in CU compared with NCU (P<0.05). There were 1558 genes differentially expressed in peripheral blood mononuclear cells between the groups (P<0.05). Integrated analysis of data identified myo-inositol related to gene clusters associated with an increase in insulin, growth factor and IGF-I signalling in CU children (P<0.05). Metabolic and transcriptomic profiles in CU SGA children showed changes that may relate to cardiometabolic risk.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Shaikh, Dr Mohammed Guftar
• Authors: Stevens, A., Bonshek, C., Whatmore, A., Butcher, I., Hanson, D., De Leonibus, C., Shaikh, G., Brown, M., O'Shea, E., Victor, S., Powell, P., Settle, P., Padmakumar, B., Tan, A., Odeka, E., Cooper, C., Birch, J., Shenoy, A., Westwood, M., Patel, L., Dunn, B. W., and Clayton, P.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Pharmacogenomics Journal
• Publisher: Springer Nature
• ISSN: 1470-269X
• ISSN (Online): 1473-1150
• Published Online: 11 March 2014