Chen, S. C., Murphy, D., Sastry, J. and Shaikh, M. G. (2015) Predicting, monitoring, and managing hypercalcemia secondary to 13-cis-retinoic acid therapy in children with high-risk neuroblastoma. Journal of Pediatric Hematology/Oncology, 37(6), pp. 477-481. (doi: 10.1097/MPH.0000000000000362) (PMID:26056798)
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Abstract
13-cis-retinoic acid is an established component of treatment for children with high-risk neuroblastoma. However, significant hypercalcemia is increasingly recognized as a potentially life-threatening dosage-related side effect. We present 2 patients with significant hypercalcemia secondary to 13-cis-retinoic acid and their management, and identified the predictive factors for susceptibility to hypercalcemia. Assessing glomerular filtration rate and concomitant medication help predict individual susceptibility to hypercalcemia. Calcium levels should be monitored at days 1, 7, and 14 of each course of retinoic acid. An algorithm for the management of hypercalcemia during the affected and subsequent cycles of retinoid therapy is proposed.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Shaikh, Dr Mohammed Guftar |
| Authors: | Chen, S. C., Murphy, D., Sastry, J., and Shaikh, M. G. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Journal of Pediatric Hematology/Oncology |
| Publisher: | Lippincott, Williams & Wilkins |
| ISSN: | 1077-4114 |
| ISSN (Online): | 1536-3678 |
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