Narayanan, V. K., Ronghe, M., MacGregor, F. B., Bradshaw, N., Davidson, R., Welbury, R., Reed, N. and Shaikh, M. G. (2016) Use of vandetanib in metastatic medullary carcinoma of thyroid in a pediatric patient with multiple endocrine neoplasia 2B. Journal of Pediatric Hematology/Oncology, 38(2), pp. 155-157. (doi: 10.1097/MPH.0000000000000432) (PMID:26479990)
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Abstract
We describe a child with advanced, metastatic, inoperable medullary carcinoma of thyroid associated with multiple endocrine neoplasia 2B and rearranged during transfection mutation with a positive response to vandetanib treatment. He responded well with a fall in calcitonin levels and a reduction in size of the thyroid malignancy, lymph nodes, and pulmonary metastases. He has been on vandetanib for 4 years with good clinical and biochemical response. Vandetanib has a role in the treatment of patients including children with inoperable locally advanced and metastatic medullary carcinoma of thyroid. More information is needed on its use in children and long-term outcome.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Shaikh, Dr Mohammed Guftar |
| Authors: | Narayanan, V. K., Ronghe, M., MacGregor, F. B., Bradshaw, N., Davidson, R., Welbury, R., Reed, N., and Shaikh, M. G. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Journal of Pediatric Hematology/Oncology |
| Publisher: | Lippincott, Williams & Wilkins |
| ISSN: | 1077-4114 |
| ISSN (Online): | 1536-3678 |
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