Gregoriou, K., Craigie, I., Gibson, B., Mason, A. and Shaikh, M. G. (2020) Risk factors and management of corticosteroid‐induced hyperglycaemia in paediatric acute lymphoblastic leukaemia. Pediatric Blood and Cancer, 67(2), e28085. (doi: 10.1002/pbc.28085) (PMID:31736211)
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Abstract
Corticosteroids are incorporated into protocols for the treatment of acute lymphoblastic leukaemia, and hyperglycaemia is a recognised side effect. Corticosteroids exert their hyperglycaemic effect with a multifactorial mechanism. Complications of hyperglycaemia include an increased risk of infection – bacterial, viral and fungal. Approximately half of the children who develop corticosteroid-associated hyperglycaemia are predicted to require insulin treatment, with age and obesity having found to be predictive factors. Fasting and random glucose values can be used to define hyperglycaemia. This review focuses on the published evidence for significant predictive factors for the development of corticosteroid-induced hyperglycaemia and provides guidance on management.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Shaikh, Dr Mohammed Guftar |
| Authors: | Gregoriou, K., Craigie, I., Gibson, B., Mason, A., and Shaikh, M. G. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Pediatric Blood and Cancer |
| Publisher: | Wiley |
| ISSN: | 1545-5009 |
| ISSN (Online): | 1545-5017 |
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