Rideout, E. J., Dornan, A. J. , Neville, M. C., Eadie, S. and Goodwin, S.F. (2010) Control of sexual differentiation and behavior by the doublesex gene in Drosophila melanogaster. Nature Neuroscience, 13(4), pp. 458-466. (doi: 10.1038/nn.2515) (PMID:20305646) (PMCID:PMC3092424)
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Abstract
Doublesex proteins, which are part of the structurally and functionally conserved Dmrt gene family, are important for sex determination throughout the animal kingdom. We inserted Gal4 into the doublesex (dsx) locus of Drosophila melanogaster, allowing us to visualize and manipulate cells expressing dsx in various tissues. In the nervous system, we detected differences between the sexes in dsx-positive neuronal numbers, axonal projections and synaptic density. We found that dsx was required for the development of male-specific neurons that coexpressed fruitless (fru), a regulator of male sexual behavior. We propose that dsx and fru act together to form the neuronal framework necessary for male sexual behavior. We found that disrupting dsx neuronal function had profound effects on male sexual behavior. Furthermore, our results suggest that dsx-positive neurons are involved in pre- to post-copulatory female reproductive behaviors.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Goodwin, Dr Stephen and Dornan, Dr Anthony |
| Authors: | Rideout, E. J., Dornan, A. J., Neville, M. C., Eadie, S., and Goodwin, S.F. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Nature Neuroscience |
| Publisher: | Nature Research |
| ISSN: | 1097-6256 |
| ISSN (Online): | 1546-1726 |
| Published Online: | 21 March 2010 |
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