A novel computational framework for simulations of bio-field effect transistors

Kumar, N. , Dhar, R. P. S., Pascual Garcia, C. and Georgiev, V. (2023) A novel computational framework for simulations of bio-field effect transistors. ECS Transactions, 111(1), pp. 249-260. (doi: 10.1149/11101.0249ecst)

Abstract

In this work, we presented a novel simulation tool called the Biomolecule-Oxide Simulator (BOxSim) and its application in simulating the behavior of BioFETs. The capabilities of BOxSim are shown by investigating the impact of various high-k dielectric materials on important Figures of Merits such as current in the channel of the device, surface potential, sensitivity, and intrinsic buffer capacitance. The capabilities of our BOxSim framework allow us to discover new features in the variation of differential capacitance with respect to the second gradient of drain current and surface potential. The profile of the surface potential is used to uniquely identify the signatures (fingerprints) of amphoteric molecules like acids or peptides. The proposed model prospects the possibility to develop an efficient method for protein sequencing. The reliability of the designed model is confirmed by calibrating the simulated results with experimental data for different physical conditions. The results presented in this paper demonstrate the potential of this framework for advancing the field of biosensors and bioelectronics for the biorecognition of different molecules.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Dhar, Rakshita Pritam Singh and Kumar, Dr Naveen and Georgiev, Professor Vihar
• Authors: Kumar, N., Dhar, R. P. S., Pascual Garcia, C., and Georgiev, V.
• College/School: College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
• Journal Name: ECS Transactions
• Publisher: The Electrochemical Society
• ISSN: 1938-5862
• ISSN (Online): 1938-6737
• Copyright Holders: Copyright © The Electrochemical Society 2023
• First Published: First published in ECS Transactions 111(1):249-260
• Publisher Policy: Reproduced in accordance with the publisher copyright policy

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
305900		Electrochemically-enabled high-throughput peptidomics for next-generation precision medicine	Vihar Georgiev	European Commission (EC)	862539	ENG - Electronics & Nanoscale Engineering