Vaccination with an Inactivated Virulent Feline Immunodeficiency Virus Engineered to Express High Levels of Env

Hosie, M.J. et al. (2005) Vaccination with an Inactivated Virulent Feline Immunodeficiency Virus Engineered to Express High Levels of Env. Journal of Virology, 79(3), pp. 1954-1957.

Abstract

An inactivated virus vaccine was prepared from a pathogenic isolate of feline immunodeficiency virus containing a mutation that eliminated an endocytic sorting signal in the envelope glycoprotein, increasing its expression on virions. Cats immunized with inactivated preparations of this modified virus exhibited strong titers of antibody to Env by enzyme-linked immunosorbent assay. Evidence of protection following challenge demonstrated the potential of this approach to lentiviral vaccination.

• Item Type: Articles
• Keywords: FIV, HIV, AIDS, vaccine
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Hosie, Professor Margaret and Neil, Professor James and Willett, Professor Brian
• Authors: Hosie, M.J., Klein, D., Binley, J.M., Dunsford, T.H., Jarrett, O., Neil, J.C., Knapp, E., Giannecchini, S., Matteucci, D., Bendinelli, M., Hoxie, J.A., and Willett, B.J.
• Subjects: S Agriculture > SF Animal culture > SF600 Veterinary Medicine
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity; College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
• Research Group: Retrovirus Research Laboratory
• Journal Name: Journal of Virology
• Journal Abbr.: J. Virol.
• Publisher: American Society for Microbiology
• ISSN: 0022-538X
• ISSN (Online): 1098-5514
• Copyright Holders: Copyright © 2005 American Society for Microbiology
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher