Application of diffusion weighted multiple boli ASL to a murine model of human African trypanosomiasis

Paterson, S., Vallatos, A. , Rodgers, J. and Holmes, W. M. (2023) Application of diffusion weighted multiple boli ASL to a murine model of human African trypanosomiasis. Scientific Reports, 13, 8684. (doi: 10.1038/s41598-023-34665-z) (PMID:37248398) (PMCID:PMC10227057)

Abstract

Human African Trypanosomiasis (HAT) is a parasitic disease originating in sub-Saharan Africa. There is limited information about the changes in the blood brain barrier (BBB) during this infection. This study is the first to apply diffusion weighted ASL (DWASL) to examine changes in BBB impairment. No significant changes in water exchange across the BBB were found during the infection, even when a loss of barrier integrity was seen using Contrast Enhanced MRI (Gd-DTPA) during the late stage of the disease. Furthermore, using multiple boli ASL (mbASL), changes in cerebral blood flow (CBF) were found during the course of infection. Overall, this study highlights the need for further study of the BBB during HAT infection to understand the complex mechanisms behind impairment.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Paterson, Samantha and Rodgers, Dr Jean and Holmes, Dr William and Vallatos, Dr Antoine
• Authors: Paterson, S., Vallatos, A., Rodgers, J., and Holmes, W. M.
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine; College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
• Journal Name: Scientific Reports
• Publisher: Nature Research
• ISSN: 2045-2322
• ISSN (Online): 2045-2322
• Copyright Holders: Copyright © 2023 The Authors
• First Published: First published in Scientific Reports 13: 8684
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
190906		EPSRC 2015 DTP	Mary Beth Kneafsey	Engineering and Physical Sciences Research Council (EPSRC)	EP/M508056/1	Research and Innovation Services