How to manage heart failure with preserved ejection fraction: Practical guidance for clinicians

Desai, A. S., Lam, C. S.P., McMurray, J. J.V. and Redfield, M. M. (2023) How to manage heart failure with preserved ejection fraction: Practical guidance for clinicians. JACC: Heart Failure, 11(6), pp. 619-636. (doi: 10.1016/j.jchf.2023.03.011) (PMID:37140514)

Abstract

Although patients with heart failure with preserved ejection fraction (HFpEF) (left ventricular ejection fraction ≥50%) comprise nearly half of those with chronic heart failure, evidence-based treatment options for this population have historically been limited. Recently, however, emerging data from prospective, randomized trials enrolling patients with HFpEF have greatly altered the range of pharmacologic options to modify disease progression in selected patients with HFpEF. In the context of this evolving landscape, clinicians are increasingly in need of practical guidance regarding the best approach to management of this growing population. In this review, we build on the recently published heart failure guidelines by integrating contemporary data from recent randomized trials to provide a contemporary framework for diagnosis and evidence-based treatment of patients with HFpEF. Where gaps in knowledge persist, we provide “best available” data from post hoc analyses of clinical trials or data from observational studies to guide management until more definitive studies are available.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: McMurray, Professor John
• Authors: Desai, A. S., Lam, C. S.P., McMurray, J. J.V., and Redfield, M. M.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: JACC: Heart Failure
• Publisher: Elsevier
• ISSN: 2213-1779
• ISSN (Online): 2213-1787
• Published Online: 03 May 2023