Emerging rhabdoviruses and human infection

Shepherd, J. G. , Davis, C. , Streicker, D. G. and Thomson, E. C. (2023) Emerging rhabdoviruses and human infection. Biology, 12(6), 878. (doi: 10.3390/biology12060878) (PMID:37372162) (PMCID:PMC10294888)

Abstract

Rhabdoviridae is a large viral family, with members infecting a diverse range of hosts including, vertebrate species, arthropods, and plants. The predominant human pathogen within the family is Rabies lyssavirus, the main cause of human rabies. While rabies is itself a neglected disease, there are other, less well studied, rhabdoviruses known to cause human infection. The increasing application of next-generation sequencing technology to clinical samples has led to the detection of several novel or rarely detected rhabdoviruses associated with febrile illness. Many of these viruses have been detected in low- and middle-income countries where the extent of human infection and the burden of disease remain largely unquantified. This review describes the rhabdoviruses other than Rabies lyssavirus that have been associated with human infection. The discovery of the Bas Congo virus and Ekpoma virus is discussed, as is the re-emergence of species such as Le Dantec virus, which has recently been detected in Africa 40 years after its initial isolation. Chandipura virus and the lyssaviruses that are known to cause human rabies are also described. Given their association with human disease, the viruses described in this review should be prioritised for further study.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Thomson, Professor Emma and Streicker, Professor Daniel and Davis, Dr Chris and Shepherd, Dr James
• Authors: Shepherd, J. G., Davis, C., Streicker, D. G., and Thomson, E. C.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
• Journal Name: Biology
• Publisher: MDPI
• ISSN: 2079-7737
• ISSN (Online): 2079-7737
• Copyright Holders: Copyright © 2023 The Authors
• First Published: First published in Biology 12(6):878
• Publisher Policy: Reproduced under a Creative Commons licence

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
307106		Epidemiology meets biotechnology: preventing viral emergence from bats	Daniel Streicker	Wellcome Trust (WELLCOTR)	217221/Z/19/Z	Institute of Biodiversity, Animal Health and Comparative Medicine
314394		Funding for Studentships MRC-University of Glasgow Centre for Virus Research	Massimo Palmarini	Medical Research Council (MRC)	MC_ST_U17020	III - Centre for Virus Research
169538		T-cell mediated evolution of hepatitis C virus during acute infection	Emma Thomson	Wellcome Trust (WELLCOTR)	102789/Z/13/Z	III-MRC-GU Centre for Virus Research
				Medical Research Council	MC_UU_1201412