Dose-response associations of dietary inflammatory potential with health outcomes: a prospective cohort study of 198,265 UK Biobank participants

Ho, F. K. et al. (2023) Dose-response associations of dietary inflammatory potential with health outcomes: a prospective cohort study of 198,265 UK Biobank participants. Current Problems in Cardiology, 48(9), 101774. (doi: 10.1016/j.cpcardiol.2023.101774) (PMID:37121456)

Abstract

Objective: To investigate the dose-response associations of dietary inflammatory potential with all-cause mortality and incident cardiovascular disease (CVD) and cancer. Methods: This was a prospective cohort study of 198,265 UK Biobank participants who completed at least one dietary assessment. A web based 24-hour recall questionnaire was used to derive the energy-adjusted dietary inflammatory index (E-DII). All-cause mortality and incident CVD and cancer ascertained from linked records. Results: After adjusting for socio-demographic and lifestyle factors, there were J-shaped associations of E-DII with all-cause mortality and CVD, and a relatively linear association with cancer. When E-DII was <0, E-DII was not associated with any of the outcomes. When E-DII was ≥0, the linear associations were strongest in all-cause mortality (HR 1.09, 95%CI 1.05-1.13), followed by CVD (HR 1.06, 95%CI 1.03-1.09), and cancer (HR 1.03, 95%CI 1.01-1.05). Conclusion: Dietary inflammatory potential was associated with mortality and CVD only when the diet is pro-inflammatory.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Celis, Dr Carlos and Nakada, Shinya and Ho, Dr Frederick and Pell, Professor Jill and Zhou, Ziyi and Hebert, Professor James and Petermann-Rocha, Mrs Fanny and Parra, Solange and Boonpor, Jirapitcha
• Authors: Ho, F. K., Wirth, M. D., Parra-Soto, S., Boonpor, J., Zhou, Z., Petermann-Rocha, F., Nakada, S., Livingstone, K. M., Mathers, J. C., Pell, J. P., Hébert, J. R., and Celis-Morales, C.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health
• Journal Name: Current Problems in Cardiology
• Publisher: Elsevier
• ISSN: 0146-2806
• ISSN (Online): 1535-6280
• Published Online: 29 April 2023
• Copyright Holders: Copyright © 2023 The Authors
• First Published: First published in Current Problems in Cardiology 48(9): 101774
• Publisher Policy: Reproduced under a Creative Commons License