Chronic kidney disease and the exposome of ageing

Shiels, P. , Tran, N. , McCavitt, J., Neytchev, O. and Stenvinkel, P. (2023) Chronic kidney disease and the exposome of ageing. In: Harris, J.R. and Korolchuk, V.I. (eds.) Biochemistry and Cell Biology of Ageing: Part IV, Clinical Science. Series: Subcellular biochemistry (103). Springer: Cham, pp. 79-94. ISBN 9783031265754 (doi: 10.1007/978-3-031-26576-1_5)

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The gap between improvements in lifespan and age-related health is widening. Globally, the demographic of ageing is increasing and there has emerged a ‘diseasome of ageing’, typified by a range of non-communicable diseases which share a common underlying component of a dysregulated ageing process. Within this, chronic kidney disease is an emerging global epidemic. The extensive inter-individual variation displayed in how people age and how their diseasome manifests and progresses, has required a renewed focus on their life course exposures and the interplay between the environment and the (epi)genome. Termed the exposome, life course abiotic and biotic factors have a significant impact on renal health. We explore how the exposome of renal ageing can predispose and affect CKD progression. We discuss how the kidney can be used as a model to understand the impact of the exposome in health and chronic kidney disease and how this might be manipulated to improve health span. Notably, we discuss the manipulation of the foodome to mitigate acceleration of ageing processes by phosphate and to explore use of emerging senotherapies. A range of senotherapies, for removing senescent cells, diminishing inflammatory burden and either directly targeting Nrf2, or manipulating it indirectly via modification of the microbiome are discussed.

Item Type:Book Sections
Additional Information:PSh is a Scientific reviewer for Mars UK Ltd and funded by an IPP award between Constant Pharma and UoG. PSt is funded by Swedish Medical Research Council, CIMED, ALF and The Heart and Lung Foundation. ON is funded by an IPP award to PS between Constant Pharma and UoG. NT is supported by MINDSHIFT—H2020-MSCA-ITN-2020, Grant Agreement number: 954798.
Glasgow Author(s) Enlighten ID:Neytchev, Ognian and Tran, Ms Ngoc and Shiels, Professor Paul
Authors: Shiels, P., Tran, N., McCavitt, J., Neytchev, O., and Stenvinkel, P.
College/School:College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
Copyright Holders:Copyright © 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG
First Published:First published in Biochemistry and Cell Biology of Ageing: Part IV, Clinical Science :79-94
Publisher Policy:Reproduced in accordance with the publisher copyright policy
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
310295MINDSHIFTRhian TouyzEuropean Commission (EC)954798CS - Epigenetics