Oncological and clinical outcomes after conventional right hemicolectomy

Ramser, M., Kwok, A. M.F., Maeda, Y. and Potter, M. A. (2021) Oncological and clinical outcomes after conventional right hemicolectomy. Langenbeck's Archives of Surgery, 406(8), pp. 2781-2788. (doi: 10.1007/s00423-021-02320-8) (PMID:34505198)

Abstract

Purpose: Complete mesocolic excision (CME) has been proposed for better local control of colon cancer and to improve cancer-specific survival (CSS). However, CME may be associated with increased morbidity from bleeding during central vascular ligation. This study aimed to investigate the outcome of conventional right hemicolectomy, a traditional anatomical dissection along anatomical planes with radical excision of the central lymph nodes at the level of the origin of colic artery but without exposure of superior mesenteric vein and artery (SMV/SMA). Method: This was a retrospective review of a cohort of all elective right hemicolectomies performed at a specialist tertiary unit during a five-year period (2011–2015). Results: Five-hundred-nineteen patients (271 female, a median age of 73.0 years (interquartile range (IQR) 65.0–80.0)) were included (Stage I disease: 2.7%, stage II: 53.2%, stage III: 33.3%, stage IV: 10.8%). At the latest follow-up (a median 47 months (IQR 29–67)), local recurrence occurred in 34 patients (6.6%). Three-year overall survival was 74.4% and 3-year CSS was 85.9%. Subgroup analysis for stage I–III showed local recurrence in 6.0%, sole distant recurrence in 7.6% while 19 patients (4.1%) suffered concomitant local and distant recurrence. The anastomotic leak rate was 1.0% and perioperative bleeding occurred in 1.2%. Conclusions: Oncological outcomes comparable to those of CME can be achieved by conventional surgery but with low rates of bleeding complications and anastomotic leakage. The proposed advantages of CME should be carefully considered and balanced against patients’ co-morbidities and potential complications.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Maeda, Miss Yasuko
• Authors: Ramser, M., Kwok, A. M.F., Maeda, Y., and Potter, M. A.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Langenbeck's Archives of Surgery
• Publisher: Springer
• ISSN: 1435-2443
• ISSN (Online): 1435-2451
• Published Online: 09 September 2021
• Copyright Holders: Copyright © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021
• First Published: First published in Langenbeck's Archives of Surgery 406(8):2781-2788
• Publisher Policy: Reproduced in accordance with the publisher copyright policy