40 Hz auditory steady state responses in schizophrenia: towards a mechanistic biomarker for circuit dysfunctions and early detection and diagnosis

Grent-'T-Jong, T. , Brickweddle, M., Metzner, C. and Uhlhaas, P. J. (2023) 40 Hz auditory steady state responses in schizophrenia: towards a mechanistic biomarker for circuit dysfunctions and early detection and diagnosis. Biological Psychiatry, (doi: 10.1016/j.biopsych.2023.03.026) (PMID:37086914) (In Press)

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There is converging evidence that 40 Hz Auditory Steady State Responses (ASSRs) are robustly impaired in schizophrenia and could constitute a potential biomarker for characterizing circuit dysfunctions as well as enable early detection and diagnosis. In the current paper, we provide an overview of the mechanisms involved in 40 Hz ASSRs, drawing on computational, physiological and pharmacological data with a focus on parameters modulating the balance between excitation/inhibition. We will then summarize findings from electro- and magnetoencephalographical studies in clinical high-risk for psychosis participants, first-episode psychosis and schizophrenia patients to identify the pattern of deficits across illness-stages, the relationship with clinical variables and prognostic potential. Finally, data on genetics and developmental modifications will be reviewed, highlighting the importance of late modifications of 40 Hz ASSRs during adolescence which are closely related to the underlying changes in gamma-aminobutyric acid interneurons. Together, our review suggests that 40 Hz ASSRs may constitute an informative electrophysiological approach to characterize circuit dysfunctions in psychosis that could be relevant for the development of mechanistic biomarkers.

Item Type:Articles
Additional Information:PJU was supported by project MR/L011689/1 from the Medical Research Council (MRC) and the ERA-NET project 01EW2007A. PJU and CM were both supported through the Einstein Stiftung Berlin (A-2020-613). PJU and MB received support through grant UH 208/4-1from the German Research Foundation (DFG).
Status:In Press
Glasgow Author(s) Enlighten ID:Uhlhaas, Professor Peter and Grent-'T-Jong, Dr Tineke
Authors: Grent-'T-Jong, T., Brickweddle, M., Metzner, C., and Uhlhaas, P. J.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Biological Psychiatry
ISSN (Online):1873-2402
Published Online:21 April 2023
Copyright Holders:Copyright © 2023 The Authors
First Published:First published in Biological Psychiatry 2023
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
190713Using Magnetoencephalography to Investigate Aberrant Neural Synchrony in Prodromal Schizophrenia: A Translational Biomarker ApproachPeter UhlhaasMedical Research Council (MRC)MR/L011689/1Centre for Cognitive Neuroimaging