Regulation of the pro-inflammatory G protein-coupled receptor GPR84

Marsango, S. and Milligan, G. (2023) Regulation of the pro-inflammatory G protein-coupled receptor GPR84. British Journal of Pharmacology, (doi: 10.1111/bph.16098) (PMID:37085331) (Early Online Publication)

Abstract

GPR84 is an understudied rhodopsin-like class A G protein-coupled receptor which is arousing particular interest from a therapeutic perspective. Not least this reflects that gpr84 expression is significantly up-regulated following acute inflammatory stimuli and in inflammatory diseases and that receptor activation plays a role in regulating pro-inflammatory responses and migration of cells of the innate immune system such as neutrophils, monocytes, macrophages and microglia. Although most physiological responses of GPR84 reflect receptor coupling to Gαi/o -proteins, several studies indicate that agonist-activated GPR84 can also recruit arrestin adaptor proteins and this regulates receptor internalisation and desensitisation. To date, little is known on the patterns of either basal or ligand regulated GPR84 phosphorylation and how these might control these processes. Here, we consider what is known about the regulation of GPR84 signalling with a focus on how G protein receptor kinase -mediated phosphorylation regulates arrestin protein recruitment and receptor function.

• Item Type: Articles
• Status: Early Online Publication
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Milligan, Professor Graeme and Marsango, Dr Sara

Creator Roles

Marsango, S.: Writing – original draft
Milligan, G.: Writing – review and editing

• Authors: Marsango, S., and Milligan, G.
• College/School: College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
• Journal Name: British Journal of Pharmacology
• Publisher: Wiley
• ISSN: 0007-1188
• ISSN (Online): 1476-5381
• Published Online: 21 April 2023
• Copyright Holders: Copyright © 2023 The Authors
• First Published: First published in British Journal of Pharmacology 2023
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
305987		IPA Responsive Mode BBSRC Resubmission GPR84	Graeme Milligan	Biotechnology and Biological Sciences Research Council (BBSRC)	BB/T000562/1	Institute of Molecular, Cell & Systems Biology