Degenaar, A., Jacobs, A., Kruger, R., Delles, C. , Mischak, H. and Mels, C.M.C. (2023) Cardiovascular risk and kidney function profiling using conventional and novel biomarkers in young adults: the African-PREDICT study. BMC Nephrology, 24, 96. (doi: 10.1186/s12882-023-03100-w) (PMID:37055746) (PMCID:PMC10103421)
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Abstract
Background: Low- and middle-income countries experience an increasing burden of chronic kidney disease. Cardiovascular risk factors, including advancing age, may contribute to this phenomenon. We (i) profiled cardiovascular risk factors and different biomarkers of subclinical kidney function and (ii) investigated the relationship between these variables. Methods: We cross-sectionally analysed 956 apparently healthy adults between 20 and 30 years of age. Cardiovascular risk factors such as high adiposity, blood pressure, glucose levels, adverse lipid profiles and lifestyle factors were measured. Various biomarkers were used to assess subclinical kidney function, including estimated glomerular filtration rate (eGFR), urinary albumin, uromodulin and the CKD273 urinary proteomics classifier. These biomarkers were used to divide the total population into quartiles to compare extremes (25th percentiles) on the normal kidney function continuum. The lower 25th percentiles of eGFR and uromodulin and the upper 25th percentiles of urinary albumin and the CKD273 classifier represented the more unfavourable kidney function groups. Results: In the lower 25th percentiles of eGFR and uromodulin and the upper 25th percentile of the CKD273 classifier, more adverse cardiovascular profiles were observed. In multi-variable adjusted regression analyses performed in the total group, eGFR associated negatively with HDL-C (β= -0.44; p < 0.001) and GGT (β= -0.24; p < 0.001), while the CKD273 classifier associated positively with age and these same risk factors (age: β = 0.10; p = 0.021, HDL-C: β = 0.23; p < 0.001, GGT: β = 0.14; p = 0.002). Conclusion: Age, lifestyle and health measures impact kidney health even in the third decade.
| Item Type: | Articles |
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| Additional Information: | Open Access funding enabled and organized by Projekt DEAL. Open access funding provided by North-West University. The research funded in this manuscript is part of an ongoing research project financially supported by the South African Medical Research Council (SAMRC) with funds from National Treasury under its Economic Competitiveness and Support Package; the South African Research Chairs Initiative (SARChI) of the Department of Science and Technology and National Research Foundation (NRF) of South Africa (GUN 86895); SAMRC with funds received from the South African National Department of Health, GlaxoSmithKline R&D (Africa Non-Communicable Disease Open Lab grant), the UK Medical Research Council and with funds from the UK Government’s Newton Fund; as well as corporate social investment grants from Pfizer (South Africa), Boehringer-Ingelheim (South Africa), Novartis (South Africa), the Mediclinic Hospital Group (South Africa) and in kind contributions of Roche Diagnostics (South Africa). CD is supported by grants from the British Heart Foundation (Research of Excellence Centre RE/18/6/34217) and the European Union (COST Action CA21165 “PerMediK”). |
| Keywords: | Age, biomarkers, cardiovascular risk factors, kidney function. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Mischak, Professor Harald and Delles, Professor Christian |
| Authors: | Degenaar, A., Jacobs, A., Kruger, R., Delles, C., Mischak, H., and Mels, C.M.C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | BMC Nephrology |
| Publisher: | BioMed Central |
| ISSN: | 1471-2369 |
| ISSN (Online): | 1471-2369 |
| Copyright Holders: | Copyright © 2023 The Authors |
| First Published: | First published in BMC Nephrology 24: 96 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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