Metabolomic profiling reveals bacterial metabolic adaptation strategies and new metabolites

Wang, H. and de Carvalho, L. P. S. (2023) Metabolomic profiling reveals bacterial metabolic adaptation strategies and new metabolites. Current Opinion in Chemical Biology, 74, 102287. (doi: 10.1016/j.cbpa.2023.102287) (PMID:36948086)

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Abstract

How has metabolomics helped our understanding of infectious diseases? With the threat of antimicrobial resistance to human health around the world, metabolomics has emerged as a powerful tool to comprehensively characterize metabolic pathways to identify new drug targets. However, its output is constrained to known metabolites and their metabolic pathways. Recent advances in instrumentation, methodologies, and computational mass spectrometry have accelerated the use of metabolomics to understand pathogen–host metabolic interactions. This short review discusses a selection of recent publications using metabolomics in infectious/bacterial diseases. These studies unravel the links between metabolic adaptations to environments and host metabolic responses. Moreover, they highlight the importance of enzyme function and metabolite characterization in identifying new drug targets and biomarkers, as well as precision medicine in monitoring therapeutics and diagnosing diseases.

Item Type:Articles
Additional Information:H.W. gratefully acknowledges the support from the University of Glasgow pump-prime funds to develop an independent research career, and the research funding support from The Royal Society (Research Grant: RGS\R2\192167) and The Academy of Medical Sciences (Springboard: SBF007\100061). The Springboard scheme is supported by the Wellcome Trust, the British Heart Foundation, the Government Department of Business, Energy, and Industrial Strategy, and Diabetes UK. Work in L.P.S.C.'s lab is funded by the Francis Crick Institute, which receives its core funding from Cancer Research UK (FC001060), the UK Medical Research Council (FC001060), and the Wellcome Trust (FC001060).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Wang, Dr Hua
Authors: Wang, H., and de Carvalho, L. P. S.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Current Opinion in Chemical Biology
Publisher:Elsevier
ISSN:1367-5931
ISSN (Online):1879-0402
Published Online:21 March 2023
Copyright Holders:Copyright © 2023 The Authors
First Published:First published in Current Opinion in Chemical Biology 74: 102287
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
307987An investigation of the Mycobacterial heme paradoxHua WangThe Royal Society (ROYSOC)RGS\R2\192167III - Bacteriology
311301The pigments of after-life: a novel Mycobacterium tuberculosis innate adaptation and persistence system.Hua WangAcademy of Medical Sciences (ACMEDSCI)SBF007\100061III - Bacteriology