Neurohumoral control of sinoatrial node activity and heart rate: insight from experimental models and findings from humans

MacDonald, E. A. , Rose, R. A. and Quinn, T. A. (2020) Neurohumoral control of sinoatrial node activity and heart rate: insight from experimental models and findings from humans. Frontiers in Physiology, 11, 170. (doi: 10.3389/fphys.2020.00170) (PMID:32194439) (PMCID:PMC7063087)

Abstract

The sinoatrial node is perhaps one of the most important tissues in the entire body: it is the natural pacemaker of the heart, making it responsible for initiating each-and-every normal heartbeat. As such, its activity is heavily controlled, allowing heart rate to rapidly adapt to changes in physiological demand. Control of sinoatrial node activity, however, is complex, occurring through the autonomic nervous system and various circulating and locally released factors. In this review we discuss the coupled-clock pacemaker system and how its manipulation by neurohumoral signaling alters heart rate, considering the multitude of canonical and non-canonical agents that are known to modulate sinoatrial node activity. For each, we discuss the principal receptors involved and known intracellular signaling and protein targets, highlighting gaps in our knowledge and understanding from experimental models and human studies that represent areas for future research.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: MacDonald, Dr Eilidh
• Authors: MacDonald, E. A., Rose, R. A., and Quinn, T. A.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Frontiers in Physiology
• Publisher: Frontiers Media
• ISSN: 1664-042X
• ISSN (Online): 1664-042X
• Published Online: 03 March 2020
• Copyright Holders: Copyright © 2020 MacDonald, Rose and Quinn
• First Published: First published in Frontiers in Physiology 11:170
• Publisher Policy: Reproduced under a Creative Commons license