Drivers and distribution of henipavirus-induced syncytia: what do we know?

Gamble, A. , Yeo, Y. Y., Butler, A. A., Tang, H., Snedden, C. E., Mason, C. T., Buchholz, D. W., Bingham, J., Aguilar, H. C. and Lloyd-Smith, J. O. (2021) Drivers and distribution of henipavirus-induced syncytia: what do we know? Viruses, 13(9), 1755. (doi: 10.3390/v13091755) (PMID:34578336) (PMCID:PMC8472861)

Abstract

Syncytium formation, i.e., cell–cell fusion resulting in the formation of multinucleated cells, is a hallmark of infection by paramyxoviruses and other pathogenic viruses. This natural mechanism has historically been a diagnostic marker for paramyxovirus infection in vivo and is now widely used for the study of virus-induced membrane fusion in vitro. However, the role of syncytium formation in within-host dissemination and pathogenicity of viruses remains poorly understood. The diversity of henipaviruses and their wide host range and tissue tropism make them particularly appropriate models with which to characterize the drivers of syncytium formation and the implications for virus fitness and pathogenicity. Based on the henipavirus literature, we summarized current knowledge on the mechanisms driving syncytium formation, mostly acquired from in vitro studies, and on the in vivo distribution of syncytia. While these data suggest that syncytium formation widely occurs across henipaviruses, hosts, and tissues, we identified important data gaps that undermined our understanding of the role of syncytium formation in virus pathogenesis. Based on these observations, we propose solutions of varying complexity to fill these data gaps, from better practices in data archiving and publication for in vivo studies, to experimental approaches in vitro.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Gamble, Dr Amandine
• Authors: Gamble, A., Yeo, Y. Y., Butler, A. A., Tang, H., Snedden, C. E., Mason, C. T., Buchholz, D. W., Bingham, J., Aguilar, H. C., and Lloyd-Smith, J. O.
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: Viruses
• Publisher: MDPI
• ISSN: 1999-4915
• ISSN (Online): 1999-4915
• Published Online: 02 September 2021
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in Viruses 13(9): 1755
• Publisher Policy: Reproduced under a Creative Commons License
• Data DOI: 10.5281/zenodo.5338802