Impact of genetic polymorphisms on the risk of epilepsy amongst patients with acute brain injury: a systematic review

Misra, S. et al. (2023) Impact of genetic polymorphisms on the risk of epilepsy amongst patients with acute brain injury: a systematic review. European Journal of Neurology, 30(6), pp. 1791-1800. (doi: 10.1111/ene.15777) (PMID:36912749)

Abstract

Background and purpose: The genetics of late seizure or epilepsy secondary to traumatic brain injury (TBI) or stroke are poorly understood. We undertook a systematic review to test the association of single-nucleotide polymorphisms (SNPs) with the risk of post-traumatic epilepsy (PTE) and post-stroke epilepsy (PSE). Methods: We followed methods from our prespecified protocol on PROSPERO to identify indexed articles for this systematic review. We collated the association statistics from the included articles to assess the association of SNPs with the risk of epilepsy amongst TBI or stroke patients. We assessed study quality using the Q-Genie tool. We report odds ratios (OR) and hazard ratios with 95% confidence intervals (CIs). Results: The literature search yielded 420 articles. We included 16 studies in our systematic review, of which seven were of poor quality. We examined published data on 127 SNPs from 32 genes identified in PTE and PSE patients. Eleven SNPs were associated with a significantly increased risk of PTE. Three SNPs, TRMP6 rs2274924, ALDH2 rs671, and CD40 -1C/T, were significantly associated with an increased risk of PSE, while two, AT1R rs12721273 and rs55707609, were significantly associated with reduced risk. The meta-analysis for the association of the APOE ɛ4 with PTE was nonsignificant (OR 1.8, CI 0.6–5.6). Conclusions: The current evidence on the association of genetic polymorphisms in epilepsy secondary to TBI or stroke is of low quality and lacks validation. A collaborative effort to pool genetic data linked to epileptogenesis in stroke and TBI patients is warranted.

• Item Type: Articles
• Additional Information: This study was supported by Yale University School of Medicine funding to Nishant K. Mishra.
• Keywords: Gene polymorphism, epilepsy, acquired brain insult, stroke, traumatic brain injury.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Quinn, Professor Terry and Dawson, Professor Jesse
• Authors: Misra, S., Quinn, T. J., Falcone, G. J., Sharma, V. K., de Havenon, A., Zhao, Y., Eldem, E., French, J. A., Yasuda, C. L., Dawson, J., Liebeskind, D. S., Kwan, P., and Mishra, N. K.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: European Journal of Neurology
• Publisher: Wiley
• ISSN: 1351-5101
• ISSN (Online): 1468-1331
• Published Online: 13 March 2023
• Copyright Holders: Copyright © 2023 European Academy of Neurology
• First Published: First published in European Journal of Neurology 30(6):1791-1800
• Publisher Policy: Reproduced in accordance with the publisher copyright policy