CYRI proteins: controllers of actin dynamics in the cellular ‘eat vs walk’ decision

Machesky, L. M. (2023) CYRI proteins: controllers of actin dynamics in the cellular ‘eat vs walk’ decision. Biochemical Society Transactions, 51(2), pp. 579-585. (doi: 10.1042/bst20221354) (PMID:36892409)

Abstract

Cells use actin-based protrusions not only to migrate, but also to sample their environment and take up liquids and particles, including nutrients, antigens and pathogens. Lamellipodia are sheet-like actin-based protrusions involved in sensing the substratum and directing cell migration. Related structures, macropinocytic cups, arise from lamellipodia ruffles and can take in large gulps of the surrounding medium. How cells regulate the balance between using lamellipodia for migration and macropinocytosis is not yet well understood. We recently identified CYRI proteins as RAC1-binding regulators of the dynamics of lamellipodia and macropinocytic events. This review discusses recent advances in our understanding of how cells regulate the balance between eating and walking by repurposing their actin cytoskeletons in response to environmental cues.

• Item Type: Articles
• Additional Information: L.M.M. is funded by CRUK core grant no. [A24452] and Human Frontiers Scientific Program Organization Programme grant no. [RGP0028/2022].
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Machesky, Professor Laura
• Authors: Machesky, L. M.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Biochemical Society Transactions
• Publisher: Portland Press
• ISSN: 0300-5127
• ISSN (Online): 1470-8752
• Published Online: 09 March 2023
• Copyright Holders: Copyright © 2023 The Author
• First Published: First published in Biochemical Society Transactions 51(2):579–585
• Publisher Policy: Reproduced under a Creative Commons License