Our current clinical understanding of Candida biofilms: where are we two decades on?

Ramage, G. , Borghi, E., Fortuna Rodrigues, C., Kean, R., Williams, C. and Lopez-Ribot, J. (2023) Our current clinical understanding of Candida biofilms: where are we two decades on? APMIS: Journal of Pathology, Microbiology and Immunology, (doi: 10.1111/apm.13310) (PMID:36932821) (Early Online Publication)

Abstract

Clinically we have been aware of the concept of Candida biofilms for many decades, though perhaps without the formal designation. Just over 20 years ago the subject emerged on the back of progress made from the bacterial biofilms, and academic progress pace has continued to mirror the bacterial biofilm community, albeit at a decreased volume. It is apparent that Candida species have a considerable capacity to colonize surfaces and interfaces and form tenacious biofilm structures, either alone or in mixed species communities. From the oral cavity, to the respiratory and genitourinary tracts, wounds, or in and around a plethora of biomedical devices, the scope of these infections is vast. These are highly tolerant to antifungal therapies that has a measurable impact on clinical management. This review aims to provide a comprehensive overight of our current clinical understanding of where these biofilms cause infections, and we discuss existing and emerging antifungal therapies and strategies.

• Item Type: Articles
• Status: Early Online Publication
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Ramage, Professor Gordon
• Authors: Ramage, G., Borghi, E., Fortuna Rodrigues, C., Kean, R., Williams, C., and Lopez-Ribot, J.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
• Journal Name: APMIS: Journal of Pathology, Microbiology and Immunology
• Publisher: Wiley
• ISSN: 0903-4641
• ISSN (Online): 1600-0463
• Published Online: 18 March 2023
• Copyright Holders: Copyright © 2023 The Authors
• First Published: First published in APMIS: Journal of Pathology, Microbiology and Immunology 2023
• Publisher Policy: Reproduced under a Creative Commons license