Cantoni, D. and Grove, J. (2023) Low hanging fruit for combatting SARS‐CoV‐2? EMBO Reports, 24(4), e56979. (doi: 10.15252/embr.202356979) (PMID:36876512) (PMCID:PMC10074046)
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Abstract
Entry of SARS-CoV-2 into human respiratory cells, mediated by the spike protein, is absolutely dependent on the cellular receptor ACE2 (angiotensin-converting enzyme-2). This makes ACE2 an attractive target for therapeutic intervention in COVID-19. In this issue, Zuo et al. discover that vitamin C, an essential nutrient and common dietary supplement, can target ACE2 for ubiquitin-dependent degradation, resulting in the inhibition of SARS-CoV-2 infection (Zuo et al, 2023). The study identifies novel mechanisms of cellular ACE2 regulation and may inform the design of therapeutics targeting SARS-2 and related coronaviruses.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Grove, Dr Joe and Cantoni, Dr Diego |
Authors: | Cantoni, D., and Grove, J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
Journal Name: | EMBO Reports |
Publisher: | EMBO Press |
ISSN: | 1469-221X |
ISSN (Online): | 1469-3178 |
Published Online: | 06 March 2023 |
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