Low hanging fruit for combatting SARS‐CoV‐2?

Cantoni, D. and Grove, J. (2023) Low hanging fruit for combatting SARS‐CoV‐2? EMBO Reports, 24(4), e56979. (doi: 10.15252/embr.202356979) (PMID:36876512) (PMCID:PMC10074046)

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Entry of SARS-CoV-2 into human respiratory cells, mediated by the spike protein, is absolutely dependent on the cellular receptor ACE2 (angiotensin-converting enzyme-2). This makes ACE2 an attractive target for therapeutic intervention in COVID-19. In this issue, Zuo et al. discover that vitamin C, an essential nutrient and common dietary supplement, can target ACE2 for ubiquitin-dependent degradation, resulting in the inhibition of SARS-CoV-2 infection (Zuo et al, 2023). The study identifies novel mechanisms of cellular ACE2 regulation and may inform the design of therapeutics targeting SARS-2 and related coronaviruses.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Grove, Dr Joe and Cantoni, Dr Diego
Authors: Cantoni, D., and Grove, J.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
Journal Name:EMBO Reports
Publisher:EMBO Press
ISSN (Online):1469-3178
Published Online:06 March 2023

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
316100Studying hepatitis C virus to determine how viruses harness structural disorder to control entry and antibody resistance.Joseph GroveWellcome Trust (WELLCOTR)107653/A/15/ZIII - Centre for Virus Research
315250MRC PE seed funding - John McLauchlanJohn McLauchlanMedical Research Council (MRC)MC_UU_12014III - Centre for Virus Research