Autophagy and autophagy-related pathways in cancer

Debnath, J., Gammoh, N. and Ryan, K. M. (2023) Autophagy and autophagy-related pathways in cancer. Nature Reviews Molecular Cell Biology, (doi: 10.1038/s41580-023-00585-z) (PMID:36864290) (PMCID:PMC9980873) (Early Online Publication)

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Maintenance of protein homeostasis and organelle integrity and function is critical for cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates the delivery of various cellular cargoes to lysosomes for degradation and recycling. A myriad of studies demonstrate important protective roles for autophagy against disease. However, in cancer, seemingly opposing roles of autophagy are observed in the prevention of early tumour development versus the maintenance and metabolic adaptation of established and metastasizing tumours. Recent studies have addressed not only the tumour cell intrinsic functions of autophagy, but also the roles of autophagy in the tumour microenvironment and associated immune cells. In addition, various autophagy-related pathways have been described, which are distinct from classical autophagy, that utilize parts of the autophagic machinery and can potentially contribute to malignant disease. Growing evidence on how autophagy and related processes affect cancer development and progression has helped guide efforts to design anticancer treatments based on inhibition or promotion of autophagy. In this Review, we discuss and dissect these different functions of autophagy and autophagy-related processes during tumour development, maintenance and progression. We outline recent findings regarding the role of these processes in both the tumour cells and the tumour microenvironment and describe advances in therapy aimed at autophagy processes in cancer.

Item Type:Articles
Additional Information:Work in the Tumour Cell Death and Autophagy Laboratory (K.R.) is supported by Cancer Research UK (A17196 and A22903). J.D. receives support from the US National Institutes of Health (CA201849, CA126792, CA213775 and AG057462), the Congressionally Directed Medical Research Program (W81XWH-22-2-0007), the Samuel Waxman Cancer Research Foundation and a Mark Foundation for Cancer Research (Endeavor Award). N.G. is supported by a Cancer Research UK fellowship (C52370/A21586).
Status:Early Online Publication
Glasgow Author(s) Enlighten ID:Ryan, Professor Kevin
Authors: Debnath, J., Gammoh, N., and Ryan, K. M.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Nature Reviews Molecular Cell Biology
Publisher:Nature Research
ISSN (Online):1471-0080
Published Online:02 March 2023

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