Angelov, A., Connelly, P. J. , Delles, C. and Kararigas, G. (2023) Sex-biased and sex hormone-dependent regulation of apolipoprotein A1. Current Opinion in Physiology, 33, 100654. (doi: 10.1016/j.cophys.2023.100654)
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Abstract
Pronounced sex differences in the development and outcome of cardiovascular diseases (CVD) exist. Apolipoprotein A1 (APOA1), the basic structural protein of high-density lipoprotein (HDL), is involved in key metabolic processes. However, its role in the pathogenesis of CVD is incompletely understood. The effects of biological sex on factors influencing the APOA1-lipid balance and the underlying mechanisms are also poorly understood. Here, we summarize evidence supporting sex-biased and sex hormone-dependent regulation of APOA1. In particular, we discuss sex-biased APOA1 genetic variation, sex differences in APOA1 regulation and cardiovascular physiology, and sex hormone-dependent regulation of APOA1 in cis- and transgender individuals. We put forward that studying the effects of biological sex will contribute to a better understanding of the role of APOA1 in cardiovascular physiology and its sex-biased association with CVD. Importantly, in situations of sex hormone therapy or inhibition, more sex-stratified data are required to inform clinical management of APOA1-related cardiovascular risk in a sex-dependent manner.
| Item Type: | Articles |
|---|---|
| Keywords: | estrogen, lipoprotein, sex, testosterone, transgender. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Delles, Professor Christian and Connelly, Dr Paul |
| Authors: | Angelov, A., Connelly, P. J., Delles, C., and Kararigas, G. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Current Opinion in Physiology |
| Publisher: | Elsevier |
| ISSN: | 2468-8681 |
| ISSN (Online): | 2468-8673 |
| Published Online: | 09 March 2023 |
| Copyright Holders: | Copyright © 2023 Elsevier Ltd. |
| First Published: | First published in Current Opinion in Physiology 33: 100654 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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