Sex-biased and sex hormone-dependent regulation of apolipoprotein A1

Angelov, A., Connelly, P. J. , Delles, C. and Kararigas, G. (2023) Sex-biased and sex hormone-dependent regulation of apolipoprotein A1. Current Opinion in Physiology, 33, 100654. (doi: 10.1016/j.cophys.2023.100654)

Abstract

Pronounced sex differences in the development and outcome of cardiovascular diseases (CVD) exist. Apolipoprotein A1 (APOA1), the basic structural protein of high-density lipoprotein (HDL), is involved in key metabolic processes. However, its role in the pathogenesis of CVD is incompletely understood. The effects of biological sex on factors influencing the APOA1-lipid balance and the underlying mechanisms are also poorly understood. Here, we summarize evidence supporting sex-biased and sex hormone-dependent regulation of APOA1. In particular, we discuss sex-biased APOA1 genetic variation, sex differences in APOA1 regulation and cardiovascular physiology, and sex hormone-dependent regulation of APOA1 in cis- and transgender individuals. We put forward that studying the effects of biological sex will contribute to a better understanding of the role of APOA1 in cardiovascular physiology and its sex-biased association with CVD. Importantly, in situations of sex hormone therapy or inhibition, more sex-stratified data are required to inform clinical management of APOA1-related cardiovascular risk in a sex-dependent manner.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Delles, Professor Christian and Connelly, Dr Paul
• Authors: Angelov, A., Connelly, P. J., Delles, C., and Kararigas, G.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Current Opinion in Physiology
• Publisher: Elsevier
• ISSN: 2468-8681
• ISSN (Online): 2468-8673
• Published Online: 09 March 2023
• Copyright Holders: Copyright © 2023 Elsevier Ltd.
• First Published: First published in Current Opinion in Physiology 33: 100654
• Publisher Policy: Reproduced in accordance with the publisher copyright policy

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
303944		BHF Centre of Excellence	Colin Berry	British Heart Foundation (BHF)	RE/18/6/34217	CAMS - Cardiovascular Science