O’Lone, E. et al. (2023) Defining myocardial infarction in trials of people receiving hemodialysis: consensus report from the SONG-HD MI expert working group. Kidney International, 103(6), pp. 1028-1037. (doi: 10.1016/j.kint.2023.02.033) (PMID:37023851)
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Abstract
Cardiovascular disease is the leading cause of death in patients receiving hemodialysis. Currently, there is no standardized definition of myocardial infarction (MI) for patients receiving hemodialysis. Through an international consensus process MI was established as the core CVD measure for this population in clinical trials. The Standardised Outcomes in Nephrology Group—Hemodialysis (SONG-HD) initiative convened a multidisciplinary, international working group to address the definition of MI in this population. On the basis of current evidence, the working group recommends using the Fourth Universal Definition of Myocardial Infarction with specific caveats with regard to the interpretation of “ischemic symptoms” and performing a baseline 12-lead electrocardiogram to facilitate interpretation of acute changes on subsequent tracings. The working group does not recommend obtaining baseline cardiac troponin values, though does recommend obtaining serial cardiac biomarkers in settings where ischemia is suspected. The application of an evidence-based uniform definition should increase the reliability and accuracy of trial results.
| Item Type: | Articles |
|---|---|
| Additional Information: | This work was supported by the National Health and Medical Research Council Australia (NHMRC; 1098815). |
| Keywords: | hemodialysis, myocardial infarction, outcome, definition, trials, recommendations. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Mark, Professor Patrick |
| Authors: | O’Lone, E., Apple, F. S., Burton, J. O., Caskey, F. J., Craig, J. C., de Filippi, C. R., Forfang, D., Hicks, K. A., Jha, V., Mahaffey, K. W., Mark, P. B., Rossignol, P., Scholes-Robertson, N., Jaure, A., Viecelli, A. K., Wang, A. Y., Wheeler, D. C., White, D., Winkelmayer, W. C., and Herzog, C. A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Kidney International |
| Publisher: | Elsevier |
| ISSN: | 0085-2538 |
| ISSN (Online): | 1523-1755 |
| Published Online: | 05 April 2023 |
| Copyright Holders: | Copyright © 2023 International Society of Nephrology |
| First Published: | First published in Kidney International 103(6):1028-1037 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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