Bicarbonate transport as regulator of antitumour immunity in pancreatic cancer

Kay, E. J. and Zanivan, S. (2023) Bicarbonate transport as regulator of antitumour immunity in pancreatic cancer. Molecular Oncology, 17(4), pp. 541-544. (doi: 10.1002/1878-0261.13400) (PMID:36807529)

Abstract

Bicarbonate transport is a pre-existing mechanism of pH regulation in pancreatic ductal cells. In a recent study, Cappellesso et al. demonstrated that pancreatic ductal adenocarcinoma metabolic rewiring creates an acidic environment, enhanced by bicarbonate import into cancer cells via SLC4A4. This acidity favours protumourigenic immunosuppression. Targeting SLC4A4 neutralises environmental pH and restores antitumour immunity, sensitising tumours to immune checkpoint blockade.

• Item Type: Articles
• Additional Information: This research was supported by funding from Stand Up to Cancer campaign for Cancer Research UK (grant no. A29800 to SZ) and Breast Cancer Now (grant no. 2018NovPR102 to SZ).
• Keywords: Acidosis, metabolism, cancer, T-cells, immunotherapy, tumour microenvironment.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Kay, Emily and Zanivan, Professor Sara
• Authors: Kay, E. J., and Zanivan, S.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Molecular Oncology
• Publisher: Wiley
• ISSN: 1574-7891
• ISSN (Online): 1878-0261
• Published Online: 21 February 2023
• Copyright Holders: Copyright © 2023 The Authors
• First Published: First published in Molecular Oncology 17(4): 541-544
• Publisher Policy: Reproduced under a Creative Commons License