Heterogeneity of cholangiocarcinoma immune biology

Vita, F., Olaizola Rebè, I., Amato, F., Rae, C. , Marco, S., Banales, J. M. and Braconi, C. (2023) Heterogeneity of cholangiocarcinoma immune biology. Cells, 12(6), 846. (doi: 10.3390/cells12060846) (PMID:36980187) (PMCID:PMC10047186)

[img] Text
293869.pdf - Published Version
Available under License Creative Commons Attribution.



Cholangiocarcinomas (CCAs) are aggressive tumors arising along the biliary tract epithelium, whose incidence and mortality are increasing. CCAs are highly desmoplastic cancers characterized by a dense tumor microenvironment (TME), in which each single component plays a fundamental role in shaping CCA initiation, progression and resistance to therapies. The crosstalk between cancer cells and TME can affect the recruitment, infiltration and differentiation of immune cells. According to the stage of the disease and to intra- and inter-patient heterogeneity, TME may contribute to either protumoral or antitumoral activities. Therefore, a better understanding of the effect of each immune cell subtype may open the path to new personalized immune therapeutic strategies for the management of CCA. In this review, we describe the role of immune cells in CCA initiation and progression, and their crosstalk with both cancer-associated fibroblasts (CAFs) and the cancer-stem-cell-like (CSC) niche.

Item Type:Articles
Additional Information:Chiara Braconi is recipient of a Lord-Kelvin–Adam-Smith readership from the University of Glasgow, an Institutional catalyst Welcome Trust award (ISSF310138), and Chief Scientist Office research grant (TCS/21/25). Francesca Vita has been recipient of a Short-Term Scientific Mission grant from EURO-CHOLANGIO-NET COST CA18122 (E-COST-GRANT-CA18122-0ae6d103).
Glasgow Author(s) Enlighten ID:Marco, Dr Sergi and Rae, Dr Colin and Amato, Francesco and Olaizola Rebe, Irene and Vita, Francesca and Braconi, Professor Chiara
Authors: Vita, F., Olaizola Rebè, I., Amato, F., Rae, C., Marco, S., Banales, J. M., and Braconi, C.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Cells
ISSN (Online):2073-4409
Published Online:08 March 2023
Copyright Holders:Copyright © 2023 The Authors
First Published:First published in Cells 12(6): 846
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
310138Liquid biopsy as a mean to promote personalized medicine in biliary cancer patientsChiara BraconiWellcome Trust (WELLCOTR)N/AInstitute of Cancer Sciences
315305Dissecting the transcriptomic and phenotypic reprogramming of monocytes that mediate chemoresistance in cholangiocarcinoma.Chiara BraconiOffice of the Chief Scientific Adviser (CSO)N/AInstitute of Cancer Sciences