Cross-reaction, enhancement, and neutralization activity of dengue virus antibodies against Zika virus: a study in the Mexican population

Montecillo-Aguado, M. R. et al. (2019) Cross-reaction, enhancement, and neutralization activity of dengue virus antibodies against Zika virus: a study in the Mexican population. Journal of Immunology Research, 2019, 7239347. (doi: 10.1155/2019/7239347) (PMID:31565661) (PMCID:PMC6745170)

Abstract

Zika virus (ZIKV), an emerging mosquito-borne flavivirus, has quickly spread in many regions around the world where dengue virus (DENV) is endemic. This represents a major health concern, given the high homology between these two viruses, which can result in cross-reactivity. The aim of this study was to determine the cross-reacting antibody response of the IgM and IgG classes against the recombinant envelope protein of ZIKV (rE-ZIKV) in sera from patients with acute-phase infection of different clinical forms of dengue, i.e., dengue fever (DF) and dengue hemorrhagic fever (DHF) (before the arrival of ZIKV in Mexico 2010), as well as acute-phase sera of ZIKV patients, together with the implications in neutralization and antibody-dependent enhancement. Differences in IgM responses were observed in a number of DF and DHF patients whose sera cross-reacted with the rE-ZIK antigen, with 42% recognition between acute-phase DHF and ZIKV but 27% recognition between DF and ZIKV. Regarding IgG antibodies, 71.5% from the DF group showed cross-reactivity to rE-ZIKV in contrast with 50% and only 25% of DHF and ZIKV serum samples, respectively, which specifically recognized the homologous antigen. The DHF group showed more enhancement of ZIKV infection of FCRγ-expressing cells compared to the DF group. Furthermore, the DHF group also showed a higher cross-neutralizing ability than that of DF. This is the first report where DF and DHF serum samples were evaluated for cross-reactivity against Zika protein and ZIKV. Furthermore, DENV serum samples cross-protect against ZIKV through neutralizing antibodies but at the same time mediate antibody-dependent enhancement in the sequential ZIKV infection.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Montes Gomez, Mr Alfredo
• Authors: Montecillo-Aguado, M. R., Montes-Gómez, A. E., García-Cordero, J., Corzo-Gómez, J., Vivanco-Cid, H., Mellado-Sánchez, G., Muñoz-Medina, J. E., Gutiérrez-Castañeda, B., Santos-Argumedo, L., González-Bonilla, C., and Cedillo-Barrón, L.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Journal of Immunology Research
• Publisher: Hindawi
• ISSN: 2314-8861
• ISSN (Online): 2314-7156
• Copyright Holders: Copyright © 2019 Mayra R. Montecillo-Aguado et al.
• First Published: First published in Journal of Immunology Research 2019: 7239347
• Publisher Policy: Reproduced under a Creative Commons License