Signalment and C-reactive protein values in dogs with immune-mediated polyarthritis and steroid responsive meningitis arteritis

Indzhova, V., Czopowicz, M., Kilpatrick, S., Gutierrez-Quintana, R. and Brocal, J. (2023) Signalment and C-reactive protein values in dogs with immune-mediated polyarthritis and steroid responsive meningitis arteritis. Frontiers in Veterinary Science, 10, 1091318. (doi: 10.3389/fvets.2023.1091318) (PMID:36865442) (PMCID:PMC9971500)

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Abstract

Introduction: This retrospective multicentric study aims to evaluate the ability of CRP concentration to differentiate between dogs diagnosed with IMPA and SRMA. C-reactive protein (CRP) is a marker of inflammation widely used in two of the most commonly diagnosed immune-mediated diseases in dogs—Immune-mediated polyarthritis (IMPA) and steroid responsive meningitis arteritis (SRMA). Materials and methods: Data collected from medical records of 167 client-owned dogs included age, breed, gender, neuter status, body weight, body temperature, CRP concentration, month and season of diagnosis. CRP was measured quantitatively in 142 dogs (84%) and semi-quantitatively in 27 dogs (16%). Results: SRMA was diagnosed significantly more often in dogs < 12 months old and IMPA in dogs ≥12 months old (P < 0.001). Dogs diagnosed with SRMA had higher CRP concentration than dogs diagnosed with IMPA (P = 0.02). This difference was influenced by the dog's age–when a dog was <12 months old, a higher CRP concentration indicated IMPA (P = 0.02), whereas when a dog was ≥12 months old, a higher CRP concentration indicated SRMA (P = 0.02). Discussion: CRP concentration as a sole diagnostic modality showed only fair discriminatory potential to differentiate between SRMA and IMPA (area under ROC curve close to 0.7). CRP concentration varied depending on patient age and definitive diagnosis. It may play some role in differentiating between SRMA and IMPA but should not be used as the sole diagnostic modality, given it has been demonstrated to only have fair discriminatory potential.

Item Type:Articles
Additional Information:Linnaeus Veterinary Limited supported the costs of Open Access Publication Charges.
Keywords:Canine (dog), inflammation, acute phase protein (APP), SRMA (steroid-responsive meningitis arteritis), IMPA, C-reactive protein.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gutierrez Quintana, Mr Rodrigo
Authors: Indzhova, V., Czopowicz, M., Kilpatrick, S., Gutierrez-Quintana, R., and Brocal, J.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Frontiers in Veterinary Science
Publisher:Frontiers Media
ISSN:2297-1769
ISSN (Online):2297-1769
Copyright Holders:Copyright © 2023 Indzhova, Czopowicz, Kilpatrick, Gutierrez-Quintana and Brocal
First Published:First published in Frontiers in Veterinary Science 10: 1091318
Publisher Policy:Reproduced under a Creative Commons License

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