MUM-1 in canine lymphoma: a pilot study

Riccardi, E., Klopfleish, R., Bell, F. , Calvez, S. L. and Dawson, L. J. (2023) MUM-1 in canine lymphoma: a pilot study. Veterinary Pathology, (doi: 10.1177/03009858231155401) (PMID:36800915) (Early Online Publication)

Abstract

Expression of interferon regulatory factor 4 (IRF4)/multiple myeloma oncogene-1 (MUM1) in peripheral T-cell lymphoma (PTCL) in people is associated with a poorer survival outcome compared to cases of PTCL lacking MUM1 expression. The aim of this study was to determine whether MUM1 is expressed in canine peripheral T-cell lymphoma not otherwise specified (PTCL-NOS). For comparison, the presence of MUM1 antigen was also investigated in canine diffuse large B cell lymphoma (DLBCL). Nine cases of PTCL-NOS and 9 cases of DLBCL diagnosed by a commercial veterinary diagnostic laboratory were selected. Positive immunohistochemical labeling for MUM1 was observed in PTCL-NOS (2 out of 9 cases) and DLBCL (3 out of 9 cases). These findings suggest that a subset of neoplastic T and B lymphocytes can express MUM1. The role of MUM1 in the biological behavior and outcome of canine lymphoma (CL) requires further investigation on a larger number of cases.

• Item Type: Articles
• Status: Early Online Publication
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Bell, Mr Frazer
• Authors: Riccardi, E., Klopfleish, R., Bell, F., Calvez, S. L., and Dawson, L. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: Veterinary Pathology
• Publisher: SAGE Publications
• ISSN: 0300-9858
• ISSN (Online): 1544-2217
• Published Online: 17 February 2023
• Copyright Holders: Copyright © The Author(s) 2023
• First Published: First published in Veterinary Pathology 2023
• Publisher Policy: Reproduced in accordance with the publisher copyright policy