Keeping it organized: multicompartment constructs to mimic tissue heterogeneity

Sanchez-Rubio, A., Jayawarna, V., Maxwell, E., Dalby, M. J. and Salmeron-Sanchez, M. (2023) Keeping it organized: multicompartment constructs to mimic tissue heterogeneity. Advanced Healthcare Materials, 12(17), 2202110. (doi: 10.1002/adhm.202202110) (PMID:36938891)

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Abstract

Tissue engineering aims at replicating tissues and organs to develop applications in vivo and in vitro. In vivo, by engineering artificial constructs using functional materials and cells to provide both physiological form and function. In vitro, by engineering 3D models to support drug discovery and enable understanding of fundamental biology. 3D culture constructs mimic cell-cell and cell-matrix interactions and use biomaterials seeking to increase the resemblance of engineered tissues with its in vivo homologues. Native tissues, however, include complex architectures, with compartmentalized regions of different properties containing different types of cells that can be captured by multicompartment constructs. Recent advances in fabrication technologies, such as micropatterning, microfluidics or 3D bioprinting, have enabled compartmentalized structures with defined compositions and properties that are essential in creating 3D cell-laden multiphasic complex architectures. This review focuses on advances in engineered multicompartment constructs that mimic tissue heterogeneity. It included multiphasic 3D implantable scaffolds and in vitro models, including systems that incorporate different regions emulating in vivo tissues, highlighting the emergence and relevance of 3D bioprinting in the future of biological research and medicine.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Salmeron-Sanchez, Professor Manuel and Jayawarna, Dr Vineetha and Sanchez-Rubio, Alvaro and Dalby, Professor Matthew
Authors: Sanchez-Rubio, A., Jayawarna, V., Maxwell, E., Dalby, M. J., and Salmeron-Sanchez, M.
College/School:College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Advanced Healthcare Materials
Publisher:Wiley
ISSN:2192-2640
ISSN (Online):2192-2659
Published Online:20 March 2023
Copyright Holders:Copyright © 2023 The Authors
First Published:First published in Advanced Healthcare Materials 12(17):2202110
Publisher Policy:Reproduced under a Creative Commons license

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
173192Engineering growth factor microenvironments- a new therapeutic paradigm for regenerative medicineManuel Salmeron-SanchezEngineering and Physical Sciences Research Council (EPSRC)EP/P001114/1ENG - Biomedical Engineering
301095UKRMP2 Acellular/Smart Materials 3D Architecture HubManuel Salmeron-SanchezMedical Research Council (MRC)MR/R015651/1ENG - Biomedical Engineering