Synthesis and characterization of two self-assembled [Cu6Gd3] and [Cu5Dy2] complexes exhibiting magnetocaloric effect, slow relaxation of magnetization and anticancer activity

Bhanja, A., Chaudhuri, S. R., Canaj, A. B. , Vyas, S. P., Ortu, F., Smythe, L., Murrie, M. , Goswami, R. and Ray, D. (2023) Synthesis and characterization of two self-assembled [Cu6Gd3] and [Cu5Dy2] complexes exhibiting magnetocaloric effect, slow relaxation of magnetization and anticancer activity. Dalton Transactions, 52(12), pp. 3795-3806. (doi: 10.1039/D2DT03932J) (PMID:36866587)

Abstract

Two new paths for coordination driven self-assembly reactions under the binding supports of 2-((1-hydroxy-2-methylpropan-2-ylimino)methyl)-6-methoxyphenol (H2L) have been discovered from reactions of Cu(ClO4)2·6H2O, NEt3 and GdCl3/DyCl3·6H2O in MeOH/CHCl3 (2:1) medium. Similar synthetic protocol is useful to provide two different types of self-aggregated molecular cluster in [Cu6Gd3(L)3(HL)3(μ3-Cl)3(μ3-OH)6(OH)2]ClO4·4H2O (1) and [Cu5Dy2(L)2(HL)2(μ-Cl)2(μ3-OH)4(ClO4)2(H2O)6](ClO4)2·2NHEt3Cl·20H2O (2). Adopted reaction procedure established the importance of the HO− and Cl− ions for the mineral-like growth of the complexes, derived from solvent and metal ion salts. In case of complex 1, one GdIII center has been trapped at the central position of the core upheld by six μ3-OH and three μ3-Cl groups whereas for complex 2 one CuII center was trapped using four μ3-hydroxo and two μ-chlorido groups. The magnetothermal behavior of 1 has been examined for a magnetocaloric effect of −ΔSm = 11.3 J kg−1 K−1 at 2 K for ΔH = 7 T. Whereas the magnetic susceptibility measurements of 2 showed slow magnetic relaxation with Ueff = 15.8 K and τ0 = 9.8 x 10−7 s in zero external dc field. Cancer cell growth inhibition studies proved the potential of both the complexes with interestingly most activity for Cu6Gd3 complex against human lung cancer cells. Both complexes 1 and 2 also exhibited DNA and human serum albumin (HSA) binding aptitudes in relation to the involved binding sites and thermodynamics.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Tsanai, Dr Angelos and Smythe, Ms Lucy and Murrie, Professor Mark
• Authors: Bhanja, A., Chaudhuri, S. R., Canaj, A. B., Vyas, S. P., Ortu, F., Smythe, L., Murrie, M., Goswami, R., and Ray, D.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Dalton Transactions
• Publisher: Royal Society of Chemistry
• ISSN: 1477-9226
• ISSN (Online): 1477-9234
• Published Online: 15 February 2023
• Copyright Holders: Copyright © 2022 The Royal Society of Chemistry
• First Published: First published in Dalton Transaction 52(12): 3795-3806
• Publisher Policy: Reproduced in accordance with the publisher copyright policy