Cinnamon: an aromatic condiment applicable to chronic kidney disease

Moreira, L. d. S. G., Brum, I. d. S. d. C., de Vargas Reis, D. C.M., Trugilho, L., Chermut, T. R., Esgalhado, M., Cardozo, L. F.M.F., Stenvinkel, P., Shiels, P. G. and Mafra, D. (2023) Cinnamon: an aromatic condiment applicable to chronic kidney disease. Kidney Research and Clinical Practice, 42(1), pp. 4-26. (doi: 10.23876/j.krcp.22.111) (PMID:36747357) (PMCID:PMC9902738)

Abstract

Cinnamon, a member of the Lauraceae family, has been widely used as a spice and traditional herbal medicine for centuries and has shown beneficial effects in cardiovascular disease, obesity, and diabetes. However, its effectiveness as a therapeutic intervention for chronic kidney disease (CKD) remains unproven. The bioactive compounds within cinnamon, such as cinnamaldehyde, cinnamic acid, and cinnamate, can mitigate oxidative stress, inflammation, hyperglycemia, gut dysbiosis, and dyslipidemia, which are common complications in patients with CKD. In this narrative review, we assess the mechanisms by which cinnamon may alleviate complications observed in CKD and the possible role of this spice as an additional nutritional strategy for this patient group.

• Item Type: Articles
• Additional Information: This study was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) number 200162/2020-9 and by Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) number E-26/202.524/2019.
• Keywords: Oxidative stress, spices, chronic renal insufficiency, inflammation, Cinnamomum zeylanicum.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Mafra, Prof Denise and Shiels, Professor Paul
• Authors: Moreira, L. d. S. G., Brum, I. d. S. d. C., de Vargas Reis, D. C.M., Trugilho, L., Chermut, T. R., Esgalhado, M., Cardozo, L. F.M.F., Stenvinkel, P., Shiels, P. G., and Mafra, D.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences; College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
• Journal Name: Kidney Research and Clinical Practice
• Publisher: Korean Society of Nephrology
• ISSN: 2211-9132
• ISSN (Online): 2211-9140
• Published Online: 31 January 2023
• Copyright Holders: Copyright © 2023 The Korean Society of Nephrology
• First Published: First published in Kidney Research and Clinical Practice 42(1): 4-26
• Publisher Policy: Reproduced under a Creative Commons License