Asymmetric parameter enhancement in the split-ring cavity array for virus-like particle sensing

Jin, X. et al. (2023) Asymmetric parameter enhancement in the split-ring cavity array for virus-like particle sensing. Biomedical Optics Express, 14(3), pp. 1216-1227. (doi: 10.1364/BOE.483831) (PMID:36950230) (PMCID:PMC10026587)

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Quantitative detection of virus-like particles under a low concentration is of vital importance for early infection diagnosis and water pollution analysis. In this paper, a novel virus detection method is proposed using indirect polarization parametric imaging method combined with a plasmonic split-ring nanocavity array coated with an Au film and a quantitative algorithm is implemented based on the extended Laplace operator. The attachment of viruses to the split-ring cavity breaks the structural symmetry, and such asymmetry can be enhanced by depositing a thin gold film on the sample, which allows an asymmetrical plasmon mode with a large shift of resonance peak generated under transverse polarization. Correspondingly, the far-field scattering state distribution encoded by the attached virus exhibits a specific asymmetric pattern that is highly correlated to the structural feature of the virus. By utilizing the parametric image sinδ to collect information on the spatial photon state distribution and far-field asymmetry with a sub-wavelength resolution, the appearance of viruses can be detected. To further reduce the background noise and enhance the asymmetric signals, an extended Laplace operator method which divides the detection area into topological units and then calculates the asymmetric parameter is applied, enabling easier determination of virus appearance. Experimental results show that the developed method can provide a detection limit as low as 56 vp/150µL on a large scale, which has great potential in early virus screening and other applications.

Item Type:Articles
Additional Information:This work was supported by the National Major Scientific Instruments and Equipment Development Project under Grant No. 61827814, Beijing Natural Science Foundation under Grant No. Z190018, National Natural Science Foundation of China (62105155), Natural Science Foundation of Jiangsu Province (BK20210326) and the Ministry of Education collaborative project (B17023). It is also supported by the UK Engineering and Physical Sciences Research Council (Grant EP/R042578/1).
Glasgow Author(s) Enlighten ID:Liu, Professor Xuefeng and Hou, Dr Lianping and Jin, Xiao and Cheng, Weiqing and Marsh, Professor John and Ye, Dr Shengwei
Authors: Jin, X., Xue, L., Ye, S., Cheng, W., Hou, J. J., Hou, L., Marsh, J. H., Sun, M., Liu, X., Xiong, J., and Ni, B.
College/School:College of Science and Engineering > School of Engineering
College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
Journal Name:Biomedical Optics Express
Publisher:Optical Society of America
ISSN (Online):2156-7085
Published Online:22 February 2023
Copyright Holders:Copyright © 2023 The Authors
First Published:First published in Biomedical Optics Express 14(3): 1216-1227
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
302617Optically controlled THz phased array antennasJohn MarshEngineering and Physical Sciences Research Council (EPSRC)EP/R042578/1ENG - Electronics & Nanoscale Engineering