Jin, X. et al. (2023) Asymmetric parameter enhancement in the split-ring cavity array for virus-like particle sensing. Biomedical Optics Express, 14(3), pp. 1216-1227. (doi: 10.1364/BOE.483831) (PMID:36950230) (PMCID:PMC10026587)
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Abstract
Quantitative detection of virus-like particles under a low concentration is of vital importance for early infection diagnosis and water pollution analysis. In this paper, a novel virus detection method is proposed using indirect polarization parametric imaging method combined with a plasmonic split-ring nanocavity array coated with an Au film and a quantitative algorithm is implemented based on the extended Laplace operator. The attachment of viruses to the split-ring cavity breaks the structural symmetry, and such asymmetry can be enhanced by depositing a thin gold film on the sample, which allows an asymmetrical plasmon mode with a large shift of resonance peak generated under transverse polarization. Correspondingly, the far-field scattering state distribution encoded by the attached virus exhibits a specific asymmetric pattern that is highly correlated to the structural feature of the virus. By utilizing the parametric image sinδ to collect information on the spatial photon state distribution and far-field asymmetry with a sub-wavelength resolution, the appearance of viruses can be detected. To further reduce the background noise and enhance the asymmetric signals, an extended Laplace operator method which divides the detection area into topological units and then calculates the asymmetric parameter is applied, enabling easier determination of virus appearance. Experimental results show that the developed method can provide a detection limit as low as 56 vp/150µL on a large scale, which has great potential in early virus screening and other applications.
| Item Type: | Articles |
|---|---|
| Additional Information: | This work was supported by the National Major Scientific Instruments and Equipment Development Project under Grant No. 61827814, Beijing Natural Science Foundation under Grant No. Z190018, National Natural Science Foundation of China (62105155), Natural Science Foundation of Jiangsu Province (BK20210326) and the Ministry of Education collaborative project (B17023). It is also supported by the UK Engineering and Physical Sciences Research Council (Grant EP/R042578/1). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Liu, Professor Xuefeng and Hou, Dr Lianping and Jin, Xiao and Cheng, Weiqing and Marsh, Professor John and Ye, Dr Shengwei |
| Authors: | Jin, X., Xue, L., Ye, S., Cheng, W., Hou, J. J., Hou, L., Marsh, J. H., Sun, M., Liu, X., Xiong, J., and Ni, B. |
| College/School: | College of Science and Engineering > School of Engineering College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering |
| Journal Name: | Biomedical Optics Express |
| Publisher: | Optical Society of America |
| ISSN: | 2156-7085 |
| ISSN (Online): | 2156-7085 |
| Published Online: | 22 February 2023 |
| Copyright Holders: | Copyright © 2023 The Authors |
| First Published: | First published in Biomedical Optics Express 14(3): 1216-1227 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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